TY - JOUR
T1 - Serum resistin concentrations and risk of new onset heart failure in older persons
T2 - The health, aging, and body composition (Health ABC) study
AU - Butler, Javed
AU - Kalogeropoulos, Andreas
AU - Georgiopoulou, Vasiliki
AU - De Rekeneire, Nathalie
AU - Rodondi, Nicolas
AU - Smith, Andrew L.
AU - Hoffmann, Udo
AU - Kanaya, Alka
AU - Newman, Anne B.
AU - Kritchevsky, Stephen B.
AU - Vasan, Ramachandran S.
AU - Wilson, Peter W.F.
AU - Harris, Tamara B.
PY - 2009/7/1
Y1 - 2009/7/1
N2 - OBJECTIVE - Resistin is associated with inflammation and insulin resistance and exerts direct effects on myocardial cells including hypertrophy and altered contraction. We investigated the association of serum resistin concentrations with risk for incident heart failure (HF) in humans. METHODS AND RESULTS - We studied 2902 older persons without prevalent HF (age, 73.6±2.9 years; 48.1% men; 58.8% white) enrolled in the Health, Aging, and Body Composition (Health ABC) Study. Correlation between baseline serum resistin concentrations (20.3±10.0 ng/mL) and clinical variables, biochemistry panel, markers of inflammation and insulin resistance, adipocytokines, and measures of adiposity was weak (all rho <0.25). During a median follow-up of 9.4 years, 341 participants (11.8%) developed HF. Resistin was strongly associated with risk for incident HF in Cox proportional hazards models controlling for clinical variables, biomarkers, and measures of adiposity (HR, 1.15 per 10.0 ng/mL in adjusted model; 95% CI, 1.05 to 1.27; P=0.003). Results were comparable across sex, race, diabetes mellitus, and prevalent and incident coronary heart disease subgroups. In participants with available left ventricular ejection fraction at HF diagnosis (265 of 341; 77.7%), association of resistin with HF risk was comparable for cases with reduced versus preserved ejection fraction. CONCLUSIONS - Serum resistin concentrations are independently associated with risk for incident HF in older persons.
AB - OBJECTIVE - Resistin is associated with inflammation and insulin resistance and exerts direct effects on myocardial cells including hypertrophy and altered contraction. We investigated the association of serum resistin concentrations with risk for incident heart failure (HF) in humans. METHODS AND RESULTS - We studied 2902 older persons without prevalent HF (age, 73.6±2.9 years; 48.1% men; 58.8% white) enrolled in the Health, Aging, and Body Composition (Health ABC) Study. Correlation between baseline serum resistin concentrations (20.3±10.0 ng/mL) and clinical variables, biochemistry panel, markers of inflammation and insulin resistance, adipocytokines, and measures of adiposity was weak (all rho <0.25). During a median follow-up of 9.4 years, 341 participants (11.8%) developed HF. Resistin was strongly associated with risk for incident HF in Cox proportional hazards models controlling for clinical variables, biomarkers, and measures of adiposity (HR, 1.15 per 10.0 ng/mL in adjusted model; 95% CI, 1.05 to 1.27; P=0.003). Results were comparable across sex, race, diabetes mellitus, and prevalent and incident coronary heart disease subgroups. In participants with available left ventricular ejection fraction at HF diagnosis (265 of 341; 77.7%), association of resistin with HF risk was comparable for cases with reduced versus preserved ejection fraction. CONCLUSIONS - Serum resistin concentrations are independently associated with risk for incident HF in older persons.
KW - Elderly
KW - Heart failure
KW - Resistin
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U2 - 10.1161/ATVBAHA.109.186783
DO - 10.1161/ATVBAHA.109.186783
M3 - Article
C2 - 19372460
AN - SCOPUS:67650287934
SN - 1079-5642
VL - 29
SP - 1144
EP - 1149
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 7
ER -