Serum proteins mediate depression's association with dementia

Donald R Royall, Safa Al-Rubaye, Ram Bishnoi, Ray Palmer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The latent variable "δ" (for "dementia") uniquely explains dementia severity. Depressive symptoms are independent predictors of δ. We explored 115 serum proteins as potential causal mediators of the effect of depressive symptoms on δ in a large, ethnically diverse, longitudinal cohort. All models were adjusted for age, apolipoprotein E, education, ethnicity, gender, hemoglobin A1c, and homocysteine, and replicated in randomly selected 50% subsets. Alpha1-antitrypsin (A1AT), FAS, Heparin-binding EGF-like Growth Factor (HB-EGF), Insulin-like Growth Factor-1 (IGF-1), Luteinizing Hormone (LH), Macrophage Inflammatory Protein type 1 alpha (MIP-1α), Resitin, S100b, Tissue Inhibitor of Metalloproteinase type 1 (TIMP-1), and Vascular Cell Adhesion Molecule type 1 (VCAM-1) each were partial mediators of depression's association with δ. These proteins may offer targets for the treatment of depression's specific effect on dementia severity and Alzheimer's Disease (AD) conversion risk.

Original languageEnglish (US)
Article numbere0175790
JournalPLoS One
Volume12
Issue number6
DOIs
StatePublished - Jun 1 2017

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Chemokine CCL3
Tissue Inhibitor of Metalloproteinase-1
dementia
Vascular Cell Adhesion Molecule-1
Apolipoproteins E
Homocysteine
Somatomedins
Luteinizing Hormone
blood proteins
Dementia
Blood Proteins
Hemoglobins
Education
Depression
apolipoprotein E
glycohemoglobin
Proteins
homocysteine
somatomedins
heparin

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Serum proteins mediate depression's association with dementia. / Royall, Donald R; Al-Rubaye, Safa; Bishnoi, Ram; Palmer, Ray.

In: PLoS One, Vol. 12, No. 6, e0175790, 01.06.2017.

Research output: Contribution to journalArticle

Royall, Donald R ; Al-Rubaye, Safa ; Bishnoi, Ram ; Palmer, Ray. / Serum proteins mediate depression's association with dementia. In: PLoS One. 2017 ; Vol. 12, No. 6.
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