Serum phospholipid fatty acids and prostate cancer risk: Results from the prostate cancer prevention trial

Theodore M. Brasky, Cathee Till, Emily White, Marian L. Neuhouser, Xiaoling Song, Phyllis Goodman, Ian M. Thompson, Irena B. King, Demetrius Albanes, Alan R. Kristal

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Inflammation may be involved in prostate cancer development and progression. This study examined the associations between inflammation-related phospholipid fatty acids and the 7-year-period prevalence of prostate cancer in a nested case-control analysis of participants, aged 55-84 years, in the Prostate Cancer Prevention Trial during 1994-2003. Cases (n = 1,658) were frequency matched to controls (n = 1,803) on age, treatment, and prostate cancer family history. Phospholipid fatty acids were extracted from serum, and concentrations of ω-3, ω-6, and trans-fatty acids (TFAs) were expressed as proportions of the total. Logistic regression models estimated odds ratios and 95% confidence intervals of associations of fatty acids with prostate cancer by grade. No fatty acids were associated with low-grade prostate cancer risk. Docosahexaenoic acid was positively associated with high-grade disease (quartile 4 vs. 1: odds ratio (OR) = 2.50, 95% confidence interval (CI): 1.34, 4.65); TFA 18:1 and TFA 18:2 were linearly and inversely associated with risk of high-grade prostate cancer (quartile 4 vs. 1: TFA 18:1, OR = 0.55, 95% CI: 0.30, 0.98; TFA 18:2, OR = 0.48, 95% CI: 0.27, 0.84). The study findings are contrary to those expected from the pro- and antiinflammatory effects of these fatty acids and suggest a greater complexity of effects of these nutrients with regard to prostate cancer risk.

Original languageEnglish (US)
Pages (from-to)1429-1439
Number of pages11
JournalAmerican journal of epidemiology
Volume173
Issue number12
DOIs
StatePublished - Jun 15 2011

Keywords

  • fatty acids
  • histology
  • inflammation
  • phospholipids
  • prostatic neoplasms
  • serum

ASJC Scopus subject areas

  • Epidemiology

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    Brasky, T. M., Till, C., White, E., Neuhouser, M. L., Song, X., Goodman, P., Thompson, I. M., King, I. B., Albanes, D., & Kristal, A. R. (2011). Serum phospholipid fatty acids and prostate cancer risk: Results from the prostate cancer prevention trial. American journal of epidemiology, 173(12), 1429-1439. https://doi.org/10.1093/aje/kwr027