Serum oxidized protein and prostate cancer risk within the prostate cancer prevention trial

Ashraful Hoque, Christine B. Ambrosone, Cathee Till, Phyllis J. Goodman, Cathy Tangen, Alan Kristal, Scott Lucia, Qiao Wang, Maya Kappil, Ian Thompson, Ann W. Hsing, Howard Parnes, Regina M. Santella

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

To evaluate the role of oxidative stress in prostate cancer risk, we analyzed serum levels of protein carbonyl groups in 1,808 prostate cancer cases and 1,805 controls, nested in the Prostate Cancer Prevention Trial, a randomized, placebo-controlled trial that found finasteride decreased prostate cancer risk. There were no significant differences in protein carbonyl levels in baseline samples between those later diagnosed with prostate cancer and those without at the end of study biopsy. Adjusted odds ratios and 95% confidence intervals (95% CI) for the 4th quartile of protein carbonyl level for the combined, placebo, and finasteride arms were 1.03 (95% CI, 0.85-1.24), 0.88 (95% CI, 0.69-1.12), and 1.27 (95% CI, 0.94-1.71), respectively. There were no significant associations between carbonyl level and risk when analyzing high-grade and low-grade disease separately, nor did finasteride affect protein oxidation levels. The results of this large nested case-control study do not support the hypothesis that oxidative stress, at least as measured by protein carbonyl level, plays a role in prostate cancer.

Original languageEnglish (US)
Pages (from-to)478-483
Number of pages6
JournalCancer Prevention Research
Volume3
Issue number4
DOIs
StatePublished - Apr 2010

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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