Serum NfL and GFAP are associated with incident dementia and dementia mortality in older adults: The cardiovascular health study

Héléne T Cronjé, Xiaojuan Liu, Michelle C Odden, Kristine F Moseholm, Sudha Seshadri, Claudia L Satizabal, Oscar L Lopez, Joshua C Bis, Luc Djoussé, Alison E Fohner, Bruce M Psaty, Russell P Tracy, W T Longstreth, Majken K Jensen, Kenneth J Mukamal

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

INTRODUCTION: Circulating neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) have been independently associated with dementia risk. Their additive association, and their associations with dementia-specific mortality, have not been investigated.

METHODS: We associated serum NfL, GFAP, total tau ,and ubiquitin carboxyl-terminal hydrolase-L1, measured in 1712 dementia-free adults, with 19-year incident dementia and dementia-specific mortality risk, and with 3-year cognitive decline.

RESULTS: In adjusted models, being in the highest versus lowest tertile of NfL or GFAP associated with a hazard ratio (HR) of 1.49 (1.20-1.84) and 1.38 (1.15-1.66) for incident dementia, and 2.87 (1.79-4.61) and 2.76 (1.73-4.40) for dementia-specific mortality. Joint third versus first tertile exposure further increased risk; HR = 2.06 (1.60-2.67) and 9.22 (4.48-18.9). NfL was independently associated with accelerated cognitive decline.

DISCUSSION: Circulating NfL and GFAP may, independently and jointly, provide useful clinical insight regarding dementia risk and prognosis.

Original languageEnglish (US)
JournalAlzheimer's and Dementia
DOIs
StateE-pub ahead of print - Jul 1 2023

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