Serum lipid levels in Sjögren's syndrome

B. M. Lodde, V. Sankar, M. R. Kok, R. A. Leakan, P. P. Tak, S. R. Pillemer

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Objectives. Altered lipid levels may occur in autoimmune diseases, for example low cholesterol levels have been described in rheumatoid arthritis (RA). Serum lipid profiles in patients with Sj̈gren's syndrome (SS) have not been investigated. We hypothesized decreased lipid levels in SS patients and an inverse relationship with disease activity. Methods. Serum lipid levels [total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and triglycerides] and additional data regarding disease measures (clinical immunology parameters, focus score from labial salivary gland biopsy, salivary flow and ophthalmological measures) were available for 46 primary SS patients and 12 xerostomic controls. Results. Significant differences between SS patients and controls means (s.d.) were seen for HDL (P=0.04) and total cholesterol (P = 0.02). LDL (P = 0.12) and triglyceride (P = 0.08) levels were not different. In SS patients, but not in controls, total cholesterol (P = 0.003) and HDL cholesterol (P = 0.003) predicted immunoglobulin G levels. Anti-SSA antibodies were related to a lower total cholesterol (P = 0.02) and anti-SSB antibodies to a lower HDL cholesterol level (P = 0.0497). Conclusions. Significant differences were seen in serum lipid levels of primary SS patients and these were associated with serological measures of inflammation. Our results are comparable to earlier findings in RA patients and raise questions related to adverse cardiovascular consequences in SS.

Original languageEnglish (US)
Pages (from-to)481-484
Number of pages4
JournalRheumatology
Volume45
Issue number4
DOIs
StatePublished - Apr 2006

Fingerprint

Lipids
Serum
Cholesterol
HDL Cholesterol
Anti-Idiotypic Antibodies
Rheumatoid Arthritis
HDL Lipoproteins
Lip
Allergy and Immunology
Salivary Glands
LDL Lipoproteins
Autoimmune Diseases
Triglycerides
Immunoglobulin G
Inflammation
Biopsy

Keywords

  • Cardiovascular disease
  • Cholesterol
  • HDL
  • Inflammation
  • Sjögren's syndrome

ASJC Scopus subject areas

  • Neuroscience(all)
  • Rheumatology

Cite this

Lodde, B. M., Sankar, V., Kok, M. R., Leakan, R. A., Tak, P. P., & Pillemer, S. R. (2006). Serum lipid levels in Sjögren's syndrome. Rheumatology, 45(4), 481-484. https://doi.org/10.1093/rheumatology/kei190

Serum lipid levels in Sjögren's syndrome. / Lodde, B. M.; Sankar, V.; Kok, M. R.; Leakan, R. A.; Tak, P. P.; Pillemer, S. R.

In: Rheumatology, Vol. 45, No. 4, 04.2006, p. 481-484.

Research output: Contribution to journalArticle

Lodde, BM, Sankar, V, Kok, MR, Leakan, RA, Tak, PP & Pillemer, SR 2006, 'Serum lipid levels in Sjögren's syndrome', Rheumatology, vol. 45, no. 4, pp. 481-484. https://doi.org/10.1093/rheumatology/kei190
Lodde BM, Sankar V, Kok MR, Leakan RA, Tak PP, Pillemer SR. Serum lipid levels in Sjögren's syndrome. Rheumatology. 2006 Apr;45(4):481-484. https://doi.org/10.1093/rheumatology/kei190
Lodde, B. M. ; Sankar, V. ; Kok, M. R. ; Leakan, R. A. ; Tak, P. P. ; Pillemer, S. R. / Serum lipid levels in Sjögren's syndrome. In: Rheumatology. 2006 ; Vol. 45, No. 4. pp. 481-484.
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