Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis

Cynthia Azeredo Cordeiro, Erica Leandro Marciano Vieira, Natália Pessoa Rocha, Vinicius Monteiro Castro, Juliana Lambert Oréfice, Tatiana Barichello, Rogerio Alves Costa, Fernando Oréfice, Lucy Young, Antonio Lucio Teixeira

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. Methods Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay. Results BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors. Conclusion BDNF may be released in the context of the active TR inflammatory response.

Original languageEnglish (US)
Pages (from-to)176-179
Number of pages4
JournalBrazilian Journal of Infectious Diseases
Issue number2
StatePublished - Mar 1 2017
Externally publishedYes


  • Brain-derived neurotrophic factor
  • Retinochoroiditis
  • Toxoplasma gondii

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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