Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis

Cynthia Azeredo Cordeiro; Erica Leandro Marciano Vieira; Natália Pessoa Rocha; Vinicius Monteiro Castro; Juliana Lambert Oréfice; Tatiana Barichello; Rogerio Alves Costa; Fernando Oréfice; Lucy Young; Antonio Lucio Teixeira

doi:10.1016/j.bjid.2016.11.005

Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis

Cynthia Azeredo Cordeiro, Erica Leandro Marciano Vieira, Natália Pessoa Rocha, Vinicius Monteiro Castro, Juliana Lambert Oréfice, Tatiana Barichello, Rogerio Alves Costa, Fernando Oréfice, Lucy Young, Antonio Lucio Teixeira

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. Methods Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay. Results BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors. Conclusion BDNF may be released in the context of the active TR inflammatory response.

Original language	English (US)
Pages (from-to)	176-179
Number of pages	4
Journal	Brazilian Journal of Infectious Diseases
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.bjid.2016.11.005
State	Published - Mar 1 2017
Externally published	Yes

Keywords

Brain-derived neurotrophic factor
Retinochoroiditis
Toxoplasma gondii

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.bjid.2016.11.005

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title = "Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis",

abstract = "Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. Methods Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay. Results BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors. Conclusion BDNF may be released in the context of the active TR inflammatory response.",

keywords = "Brain-derived neurotrophic factor, Retinochoroiditis, Toxoplasma gondii",

author = "Cordeiro, {Cynthia Azeredo} and Vieira, {Erica Leandro Marciano} and Rocha, {Nat{\'a}lia Pessoa} and Castro, {Vinicius Monteiro} and Or{\'e}fice, {Juliana Lambert} and Tatiana Barichello and Costa, {Rogerio Alves} and Fernando Or{\'e}fice and Lucy Young and Teixeira, {Antonio Lucio}",

note = "Publisher Copyright: {\textcopyright} 2016 Sociedade Brasileira de Infectologia",

year = "2017",

month = mar,

day = "1",

doi = "10.1016/j.bjid.2016.11.005",

language = "English (US)",

volume = "21",

pages = "176--179",

journal = "Brazilian Journal of Infectious Diseases",

issn = "1413-8670",

publisher = "Elsevier Editora Ltda",

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TY - JOUR

T1 - Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis

AU - Cordeiro, Cynthia Azeredo

AU - Vieira, Erica Leandro Marciano

AU - Rocha, Natália Pessoa

AU - Castro, Vinicius Monteiro

AU - Oréfice, Juliana Lambert

AU - Barichello, Tatiana

AU - Costa, Rogerio Alves

AU - Oréfice, Fernando

AU - Young, Lucy

AU - Teixeira, Antonio Lucio

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. Methods Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay. Results BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors. Conclusion BDNF may be released in the context of the active TR inflammatory response.

AB - Toxoplasmic retinochoroiditis (TR) is the most common identifiable cause of posterior uveitis in Brazil. Response to treatment and clinical presentation may vary significantly. We assessed serum levels of brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), nerve growth factor (NGF), neurotrophin (NT)-3, and NT-4/5 in patients with active TR, before and after TR treatment. Methods Twenty patients with active lesion and 15 healthy controls were enrolled in the study. Serum concentration of neurotrophic factors was determined by enzyme-linked immunosorbent assay. Results BDNF levels were significantly higher in patients before treatment when compared with controls (p = 0.0015). There was no significant difference in pro-BDNF, NGF, GDNF, NT-3, and NT-4/5 levels between TR patients and controls. Treatment did not affect the levels of these factors. Conclusion BDNF may be released in the context of the active TR inflammatory response.

KW - Brain-derived neurotrophic factor

KW - Retinochoroiditis

KW - Toxoplasma gondii

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Serum levels of neurotrophic factors in active toxoplasmic retinochoroiditis

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