TY - JOUR
T1 - Serum levels of interleukin-6 are elevated in patients with Parkinson's disease and correlate with physical performance
AU - Scalzo, Paula
AU - Kümmer, Arthur
AU - Cardoso, Francisco
AU - Teixeira, Antônio Lúcio
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Some studies have demonstrated altered circulating levels of cytokines, including IL-6, in Parkinson's disease (PD), implying a possible involvement of inflammatory and immune-mediated mechanisms in its pathogenesis. Moreover, the increased production of inflammatory cytokines has been associated with cognitive impairment and poor physical performance in the elderly. We compared serum levels of IL-6 in 44 PD patients and 22 healthy subjects, and correlated them with PD specific instruments and functional tests. Serum levels of IL-6 were significantly increased in PD (p = 0.015). There was no correlation between serum levels of IL-6 and instruments traditionally used to assess PD severity. However, we found that PD patients with higher serum levels of IL-6 spent more time at functional mobility tests and had lower gait speed. Also, these patients had major problems to keep balance during functional tasks that required postural changes and that had a reduced base support. These results showed that high levels of IL-6 can be involved with an acceleration of muscle catabolism leading to sarcopenia, therefore contributing to weakness and fatigue, and may also be associated with functional disability in PD.
AB - Some studies have demonstrated altered circulating levels of cytokines, including IL-6, in Parkinson's disease (PD), implying a possible involvement of inflammatory and immune-mediated mechanisms in its pathogenesis. Moreover, the increased production of inflammatory cytokines has been associated with cognitive impairment and poor physical performance in the elderly. We compared serum levels of IL-6 in 44 PD patients and 22 healthy subjects, and correlated them with PD specific instruments and functional tests. Serum levels of IL-6 were significantly increased in PD (p = 0.015). There was no correlation between serum levels of IL-6 and instruments traditionally used to assess PD severity. However, we found that PD patients with higher serum levels of IL-6 spent more time at functional mobility tests and had lower gait speed. Also, these patients had major problems to keep balance during functional tasks that required postural changes and that had a reduced base support. These results showed that high levels of IL-6 can be involved with an acceleration of muscle catabolism leading to sarcopenia, therefore contributing to weakness and fatigue, and may also be associated with functional disability in PD.
KW - Interleukin-6
KW - Parkinson's disease
KW - Physical performance
KW - Sarcopenia
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UR - http://www.scopus.com/inward/citedby.url?scp=70449535888&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2009.10.062
DO - 10.1016/j.neulet.2009.10.062
M3 - Article
C2 - 19857551
AN - SCOPUS:70449535888
SN - 0304-3940
VL - 468
SP - 56
EP - 58
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -