Serum levels of brain-derived neurotrophic factor in Sydenham's chorea

Antônio Lúcio Teixeira; Thales Lage Bretas; Arthur Kummer; Lívia Cunha Melo; Amanda Baraldi; Estefânia Harsányi; Francisco Cardoso; Elizabeth Ribeiro Da Silva Camargos

doi:10.1007/s10072-009-0209-5

Serum levels of brain-derived neurotrophic factor in Sydenham's chorea

Antônio Lúcio Teixeira, Thales Lage Bretas, Arthur Kummer, Lívia Cunha Melo, Amanda Baraldi, Estefânia Harsányi, Francisco Cardoso, Elizabeth Ribeiro Da Silva Camargos

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Sydenham's chorea (SC) is the neurologic manifestation of rheumatic fever. In addition to involuntary movements, SC patients show behavioral changes, such as hyperactivity, obsessions, and compulsions. Brain-derived neurotrophic factor (BDNF) is related to neuronal development and differentiation. Since BDNF serum levels are altered in a series of neuropsychiatric disorders, such as schizophrenia and Huntington's disease, we investigated the serum levels of BDNF in SC patients. Eighteen patients with acute SC, 4 with persistent SC and 27 control subjects were included in this study. BDNF was determined by ELISA. There was no significant difference between BDNF serum levels of control and acute SC groups (P = 0.12). Persistent SC patients presented decreased BDNF levels when compared to both control and acute SC groups (P<0.001). Our results suggest that the persistence of symptoms in SC may be related to structural changes in the central nervous system as expressed by altered BDNF levels.

Original language	English (US)
Pages (from-to)	399-401
Number of pages	3
Journal	Neurological Sciences
Volume	31
Issue number	3
DOIs	https://doi.org/10.1007/s10072-009-0209-5
State	Published - Jun 2010
Externally published	Yes

Keywords

BDNF
Rheumatic fever
Sydenham's chorea

ASJC Scopus subject areas

Dermatology
Clinical Neurology
Psychiatry and Mental health

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10.1007/s10072-009-0209-5

Cite this

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title = "Serum levels of brain-derived neurotrophic factor in Sydenham's chorea",

abstract = "Sydenham's chorea (SC) is the neurologic manifestation of rheumatic fever. In addition to involuntary movements, SC patients show behavioral changes, such as hyperactivity, obsessions, and compulsions. Brain-derived neurotrophic factor (BDNF) is related to neuronal development and differentiation. Since BDNF serum levels are altered in a series of neuropsychiatric disorders, such as schizophrenia and Huntington's disease, we investigated the serum levels of BDNF in SC patients. Eighteen patients with acute SC, 4 with persistent SC and 27 control subjects were included in this study. BDNF was determined by ELISA. There was no significant difference between BDNF serum levels of control and acute SC groups (P = 0.12). Persistent SC patients presented decreased BDNF levels when compared to both control and acute SC groups (P<0.001). Our results suggest that the persistence of symptoms in SC may be related to structural changes in the central nervous system as expressed by altered BDNF levels.",

keywords = "BDNF, Rheumatic fever, Sydenham's chorea",

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doi = "10.1007/s10072-009-0209-5",

language = "English (US)",

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AU - Teixeira, Antônio Lúcio

AU - Bretas, Thales Lage

AU - Kummer, Arthur

AU - Melo, Lívia Cunha

AU - Baraldi, Amanda

AU - Harsányi, Estefânia

AU - Cardoso, Francisco

AU - Da Silva Camargos, Elizabeth Ribeiro

PY - 2010/6

Y1 - 2010/6

N2 - Sydenham's chorea (SC) is the neurologic manifestation of rheumatic fever. In addition to involuntary movements, SC patients show behavioral changes, such as hyperactivity, obsessions, and compulsions. Brain-derived neurotrophic factor (BDNF) is related to neuronal development and differentiation. Since BDNF serum levels are altered in a series of neuropsychiatric disorders, such as schizophrenia and Huntington's disease, we investigated the serum levels of BDNF in SC patients. Eighteen patients with acute SC, 4 with persistent SC and 27 control subjects were included in this study. BDNF was determined by ELISA. There was no significant difference between BDNF serum levels of control and acute SC groups (P = 0.12). Persistent SC patients presented decreased BDNF levels when compared to both control and acute SC groups (P<0.001). Our results suggest that the persistence of symptoms in SC may be related to structural changes in the central nervous system as expressed by altered BDNF levels.

AB - Sydenham's chorea (SC) is the neurologic manifestation of rheumatic fever. In addition to involuntary movements, SC patients show behavioral changes, such as hyperactivity, obsessions, and compulsions. Brain-derived neurotrophic factor (BDNF) is related to neuronal development and differentiation. Since BDNF serum levels are altered in a series of neuropsychiatric disorders, such as schizophrenia and Huntington's disease, we investigated the serum levels of BDNF in SC patients. Eighteen patients with acute SC, 4 with persistent SC and 27 control subjects were included in this study. BDNF was determined by ELISA. There was no significant difference between BDNF serum levels of control and acute SC groups (P = 0.12). Persistent SC patients presented decreased BDNF levels when compared to both control and acute SC groups (P<0.001). Our results suggest that the persistence of symptoms in SC may be related to structural changes in the central nervous system as expressed by altered BDNF levels.

KW - BDNF

KW - Rheumatic fever

KW - Sydenham's chorea

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Serum levels of brain-derived neurotrophic factor in Sydenham's chorea

Abstract

Keywords

ASJC Scopus subject areas

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