Serum levels of adiponectin, CCL3/MIP-1α, and CCl5/RANTES discriminate migraine from tension-type headache patients

Renan B. Domingues, Halina Duarte, Carlos Senne, Gustavo Bruniera, Fernando Brunale, Natália P. Rocha, Antonio L. Teixeira

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Objectives: Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and tension-type headache. Methods: This was a cross-sectional study. We measured serum levels of adiponectin, chemokines, and neurotrophic factors in patients with migraine and tension-type headache. Depression and anxiety symptoms, headache impact and frequency, and allodynia were recorded. Results: We included sixty-eight patients with migraine and forty-eight with tension-type headache. Cutaneous allodynia (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), and ADP (p = 0.017) were significantly higher in migraine than in tension-type headache. The differences occurred independently of anxiety and depressive symptoms, frequency and impact of headache, and the presence of pain. Conclusions: This study showed higher CCL3/MIP-1α, CCL5/RANTES, and ADP levels in migraine in comparison with tension-type headache. Our findings suggest distinctive roles of these molecules in the pathophysiology of these primary headaches.

Original languageEnglish (US)
Pages (from-to)626-631
Number of pages6
JournalArquivos de neuro-psiquiatria
Volume74
Issue number8
DOIs
StatePublished - Aug 2016
Externally publishedYes

Keywords

  • Adiponectin
  • Chemokines
  • Migraine disorders
  • Neurotrophic factors
  • Tension-type headache

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry

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