TY - JOUR
T1 - Serum levels of adiponectin, CCL3/MIP-1α, and CCl5/RANTES discriminate migraine from tension-type headache patients
AU - Domingues, Renan B.
AU - Duarte, Halina
AU - Senne, Carlos
AU - Bruniera, Gustavo
AU - Brunale, Fernando
AU - Rocha, Natália P.
AU - Teixeira, Antonio L.
N1 - Publisher Copyright:
© 2016, Associacao Arquivos de Neuro-Psiquiatria. All rights reseved.
PY - 2016/8
Y1 - 2016/8
N2 - Objectives: Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and tension-type headache. Methods: This was a cross-sectional study. We measured serum levels of adiponectin, chemokines, and neurotrophic factors in patients with migraine and tension-type headache. Depression and anxiety symptoms, headache impact and frequency, and allodynia were recorded. Results: We included sixty-eight patients with migraine and forty-eight with tension-type headache. Cutaneous allodynia (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), and ADP (p = 0.017) were significantly higher in migraine than in tension-type headache. The differences occurred independently of anxiety and depressive symptoms, frequency and impact of headache, and the presence of pain. Conclusions: This study showed higher CCL3/MIP-1α, CCL5/RANTES, and ADP levels in migraine in comparison with tension-type headache. Our findings suggest distinctive roles of these molecules in the pathophysiology of these primary headaches.
AB - Objectives: Inflammatory molecules and neurotrophic factors are implicated in pain modulation; however, their role in primary headaches is not yet clear. The aim of this study was to compare the levels of serum biomarkers in migraine and tension-type headache. Methods: This was a cross-sectional study. We measured serum levels of adiponectin, chemokines, and neurotrophic factors in patients with migraine and tension-type headache. Depression and anxiety symptoms, headache impact and frequency, and allodynia were recorded. Results: We included sixty-eight patients with migraine and forty-eight with tension-type headache. Cutaneous allodynia (p = 0.035), CCL3/MIP-1α (p = 0.041), CCL5/RANTES (p = 0.013), and ADP (p = 0.017) were significantly higher in migraine than in tension-type headache. The differences occurred independently of anxiety and depressive symptoms, frequency and impact of headache, and the presence of pain. Conclusions: This study showed higher CCL3/MIP-1α, CCL5/RANTES, and ADP levels in migraine in comparison with tension-type headache. Our findings suggest distinctive roles of these molecules in the pathophysiology of these primary headaches.
KW - Adiponectin
KW - Chemokines
KW - Migraine disorders
KW - Neurotrophic factors
KW - Tension-type headache
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U2 - 10.1590/0004-282X20160096
DO - 10.1590/0004-282X20160096
M3 - Article
C2 - 27556373
AN - SCOPUS:84983247260
SN - 0004-282X
VL - 74
SP - 626
EP - 631
JO - Arquivos de neuro-psiquiatria
JF - Arquivos de neuro-psiquiatria
IS - 8
ER -