Serum iron metabolism and erythropoiesis in patients with myelodysplastic syndrome not receiving RBC transfusions

Rui Cui, Robert Peter Gale, Guoqing Zhu, Zefeng Xu, Tiejun Qin, Yue Zhang, Gang Huang, Bing Li, Liwei Fang, Hongli Zhang, Lijuan Pan, Naibo Hu, Shiqiang Qu, Zhijian Xiao

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Dysregulation of hepcidin, a key iron regulating hormone, is important in the pathogenesis of iron overload in patients with myelodysplatic syndrome (MDS). However, most studies of hepcidin levels are complicated by concomitant RBC transfusions. To evaluate the relationship between iron metabolism and erythropoiesis, we measured serum levels of hepcidin, growth-differentiation factor-15 (GDF15) and other markers of erythropoiesis in 107 subjects with MDS not receiving RBC transfusions. Patients with MDS had significantly higher levels of hepcidin than normals. However, their hepcidin-ferritin ratio was markedly decreased compared to normals (P< 0.001) and varied substantially between MDS subtypes (P= 0.011). GDF15 levels positively correlated with percent of bone marrow erythroblasts (P< 0.001), soluble transferrin receptor (sTfR) (P= 0.018), and also with transferrin saturation (ISAT) (P= 0.038). The hepcidin-ferritin ratio negatively correlated with serum erythropoietin (EPO) levels (P< 0.001), and also with GDF15 levels (P= 0.014). Colony forming cells (CFC) were evaluated in 70 subjects. Those with serum ferritin (SF) levels <500. ng/ml had significantly more BFU-E than subjects with SF. ≥. 500. ng/L (P= 0.007), but numbers of granulocyte/macrophage-colony-forming cells (CFU-GM) were similar (P= 0.190). Our data indicate serum hepcidin levels are inappropriately low in patients MDS not receiving RBC transfusions. GDF15 levels correlated with low hepcidin levels and may contribute to iron overload in this setting. Iron overload may in turn suppress erythropoiesis by imparing the proliferative capacity of the erythroid progenitor cells.

Original languageEnglish (US)
Pages (from-to)545-550
Number of pages6
JournalLeukemia Research
Volume38
Issue number5
DOIs
StatePublished - May 2014
Externally publishedYes

Keywords

  • Hematopoiesis
  • Iron metabolism
  • Myelodysplastic syndromes

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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