Abstract
Background and Purpose - Low insulin-like growth factor 1 (IGF-1) has been associated with increased risk of atherosclerosis and atrial fibrillation in cross-sectional studies. Yet, prospective data linking IGF-1 levels to the development of ischemic stroke remain inconclusive. We examined prospectively the association between serum IGF-1 levels and incident ischemic stroke. Methods - We measured serum IGF-1 levels in 757 elderly individuals (mean age 79±5, 62% women), free of prevalent stroke, from the Framingham original cohort participants at the 22nd examination cycle (1990-1994) and were followed up for the development of ischemic stroke. Cox models were used to relate IGF-1 levels to the risk for incident ischemic stroke, adjusted for potential confounders. Results - During a mean follow-up of 10.2 years, 99 individuals developed ischemic stroke. After adjustment for age, sex, and potential confounders, higher IGF-1 levels were associated with a lower risk of incident ischemic stroke, with subjects in the lowest quintile of IGF-1 levels having a 2.3-fold higher risk of incident ischemic stroke (95% confidence interval, 1.09-5.06; P=0.03) as compared with those in the top quintile. We observed an effect modification by diabetes mellitus and waist-hip ratio for the association between IGF-1 and ischemic stroke (P<0.1). In subgroup analyses, the effects were restricted to subjects with diabetics and those in top waist-hip ratio quartile, in whom each standard deviation increase in IGF-1 was associated with a 61% (hazard ratio, 0.39; 95% confidence interval, 0.20-0.78; P=0.007) and 41% (hazard ratio, 0.59; 95% confidence interval, 0.37-0.95; P=0.031) lower risk of incident ischemic stroke, respectively. Conclusions - IGF-1 levels were inversely associated with ischemic stroke, especially among persons with insulin resistance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1760-1765 |
| Number of pages | 6 |
| Journal | Stroke |
| Volume | 48 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 1 2017 |
| Externally published | Yes |
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Keywords
- atrial fibrillation
- IGF-1
- insulin resistance
- ischemic stroke
- risk
ASJC Scopus subject areas
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
- Advanced and Specialized Nursing
Cite this
Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke. / Saber, Hamidreza; Himali, Jayandra J.; Beiser, Alexa S.; Shoamanesh, Ashkan; Pikula, Aleksandra; Roubenoff, Ronenn; Romero, Jose R.; Kase, Carlos S.; Vasan, Ramachandran S.; Seshadri, Sudha.
In: Stroke, Vol. 48, No. 7, 01.07.2017, p. 1760-1765.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke
AU - Saber, Hamidreza
AU - Himali, Jayandra J.
AU - Beiser, Alexa S.
AU - Shoamanesh, Ashkan
AU - Pikula, Aleksandra
AU - Roubenoff, Ronenn
AU - Romero, Jose R.
AU - Kase, Carlos S.
AU - Vasan, Ramachandran S.
AU - Seshadri, Sudha
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background and Purpose - Low insulin-like growth factor 1 (IGF-1) has been associated with increased risk of atherosclerosis and atrial fibrillation in cross-sectional studies. Yet, prospective data linking IGF-1 levels to the development of ischemic stroke remain inconclusive. We examined prospectively the association between serum IGF-1 levels and incident ischemic stroke. Methods - We measured serum IGF-1 levels in 757 elderly individuals (mean age 79±5, 62% women), free of prevalent stroke, from the Framingham original cohort participants at the 22nd examination cycle (1990-1994) and were followed up for the development of ischemic stroke. Cox models were used to relate IGF-1 levels to the risk for incident ischemic stroke, adjusted for potential confounders. Results - During a mean follow-up of 10.2 years, 99 individuals developed ischemic stroke. After adjustment for age, sex, and potential confounders, higher IGF-1 levels were associated with a lower risk of incident ischemic stroke, with subjects in the lowest quintile of IGF-1 levels having a 2.3-fold higher risk of incident ischemic stroke (95% confidence interval, 1.09-5.06; P=0.03) as compared with those in the top quintile. We observed an effect modification by diabetes mellitus and waist-hip ratio for the association between IGF-1 and ischemic stroke (P<0.1). In subgroup analyses, the effects were restricted to subjects with diabetics and those in top waist-hip ratio quartile, in whom each standard deviation increase in IGF-1 was associated with a 61% (hazard ratio, 0.39; 95% confidence interval, 0.20-0.78; P=0.007) and 41% (hazard ratio, 0.59; 95% confidence interval, 0.37-0.95; P=0.031) lower risk of incident ischemic stroke, respectively. Conclusions - IGF-1 levels were inversely associated with ischemic stroke, especially among persons with insulin resistance.
AB - Background and Purpose - Low insulin-like growth factor 1 (IGF-1) has been associated with increased risk of atherosclerosis and atrial fibrillation in cross-sectional studies. Yet, prospective data linking IGF-1 levels to the development of ischemic stroke remain inconclusive. We examined prospectively the association between serum IGF-1 levels and incident ischemic stroke. Methods - We measured serum IGF-1 levels in 757 elderly individuals (mean age 79±5, 62% women), free of prevalent stroke, from the Framingham original cohort participants at the 22nd examination cycle (1990-1994) and were followed up for the development of ischemic stroke. Cox models were used to relate IGF-1 levels to the risk for incident ischemic stroke, adjusted for potential confounders. Results - During a mean follow-up of 10.2 years, 99 individuals developed ischemic stroke. After adjustment for age, sex, and potential confounders, higher IGF-1 levels were associated with a lower risk of incident ischemic stroke, with subjects in the lowest quintile of IGF-1 levels having a 2.3-fold higher risk of incident ischemic stroke (95% confidence interval, 1.09-5.06; P=0.03) as compared with those in the top quintile. We observed an effect modification by diabetes mellitus and waist-hip ratio for the association between IGF-1 and ischemic stroke (P<0.1). In subgroup analyses, the effects were restricted to subjects with diabetics and those in top waist-hip ratio quartile, in whom each standard deviation increase in IGF-1 was associated with a 61% (hazard ratio, 0.39; 95% confidence interval, 0.20-0.78; P=0.007) and 41% (hazard ratio, 0.59; 95% confidence interval, 0.37-0.95; P=0.031) lower risk of incident ischemic stroke, respectively. Conclusions - IGF-1 levels were inversely associated with ischemic stroke, especially among persons with insulin resistance.
KW - atrial fibrillation
KW - IGF-1
KW - insulin resistance
KW - ischemic stroke
KW - risk
UR - http://www.scopus.com/inward/record.url?scp=85020628937&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020628937&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.116.016563
DO - 10.1161/STROKEAHA.116.016563
M3 - Article
C2 - 28596451
AN - SCOPUS:85020628937
VL - 48
SP - 1760
EP - 1765
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 7
ER -