Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke

Hamidreza Saber, Jayandra J. Himali, Alexa S. Beiser, Ashkan Shoamanesh, Aleksandra Pikula, Ronenn Roubenoff, Jose R. Romero, Carlos S. Kase, Ramachandran S. Vasan, Sudha Seshadri

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background and Purpose - Low insulin-like growth factor 1 (IGF-1) has been associated with increased risk of atherosclerosis and atrial fibrillation in cross-sectional studies. Yet, prospective data linking IGF-1 levels to the development of ischemic stroke remain inconclusive. We examined prospectively the association between serum IGF-1 levels and incident ischemic stroke. Methods - We measured serum IGF-1 levels in 757 elderly individuals (mean age 79±5, 62% women), free of prevalent stroke, from the Framingham original cohort participants at the 22nd examination cycle (1990-1994) and were followed up for the development of ischemic stroke. Cox models were used to relate IGF-1 levels to the risk for incident ischemic stroke, adjusted for potential confounders. Results - During a mean follow-up of 10.2 years, 99 individuals developed ischemic stroke. After adjustment for age, sex, and potential confounders, higher IGF-1 levels were associated with a lower risk of incident ischemic stroke, with subjects in the lowest quintile of IGF-1 levels having a 2.3-fold higher risk of incident ischemic stroke (95% confidence interval, 1.09-5.06; P=0.03) as compared with those in the top quintile. We observed an effect modification by diabetes mellitus and waist-hip ratio for the association between IGF-1 and ischemic stroke (P<0.1). In subgroup analyses, the effects were restricted to subjects with diabetics and those in top waist-hip ratio quartile, in whom each standard deviation increase in IGF-1 was associated with a 61% (hazard ratio, 0.39; 95% confidence interval, 0.20-0.78; P=0.007) and 41% (hazard ratio, 0.59; 95% confidence interval, 0.37-0.95; P=0.031) lower risk of incident ischemic stroke, respectively. Conclusions - IGF-1 levels were inversely associated with ischemic stroke, especially among persons with insulin resistance.

Original languageEnglish (US)
Pages (from-to)1760-1765
Number of pages6
JournalStroke
Volume48
Issue number7
DOIs
StatePublished - Jul 1 2017
Externally publishedYes

Fingerprint

Somatomedins
Stroke
Serum
Waist-Hip Ratio
Confidence Intervals
Proportional Hazards Models
Atrial Fibrillation
Insulin Resistance
Atherosclerosis
Diabetes Mellitus
Cross-Sectional Studies

Keywords

  • atrial fibrillation
  • IGF-1
  • insulin resistance
  • ischemic stroke
  • risk

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Saber, H., Himali, J. J., Beiser, A. S., Shoamanesh, A., Pikula, A., Roubenoff, R., ... Seshadri, S. (2017). Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke. Stroke, 48(7), 1760-1765. https://doi.org/10.1161/STROKEAHA.116.016563

Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke. / Saber, Hamidreza; Himali, Jayandra J.; Beiser, Alexa S.; Shoamanesh, Ashkan; Pikula, Aleksandra; Roubenoff, Ronenn; Romero, Jose R.; Kase, Carlos S.; Vasan, Ramachandran S.; Seshadri, Sudha.

In: Stroke, Vol. 48, No. 7, 01.07.2017, p. 1760-1765.

Research output: Contribution to journalArticle

Saber, H, Himali, JJ, Beiser, AS, Shoamanesh, A, Pikula, A, Roubenoff, R, Romero, JR, Kase, CS, Vasan, RS & Seshadri, S 2017, 'Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke', Stroke, vol. 48, no. 7, pp. 1760-1765. https://doi.org/10.1161/STROKEAHA.116.016563
Saber H, Himali JJ, Beiser AS, Shoamanesh A, Pikula A, Roubenoff R et al. Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke. Stroke. 2017 Jul 1;48(7):1760-1765. https://doi.org/10.1161/STROKEAHA.116.016563
Saber, Hamidreza ; Himali, Jayandra J. ; Beiser, Alexa S. ; Shoamanesh, Ashkan ; Pikula, Aleksandra ; Roubenoff, Ronenn ; Romero, Jose R. ; Kase, Carlos S. ; Vasan, Ramachandran S. ; Seshadri, Sudha. / Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke. In: Stroke. 2017 ; Vol. 48, No. 7. pp. 1760-1765.
@article{5472632e678a4b7d9053f1b1b5229927,
title = "Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke",
abstract = "Background and Purpose - Low insulin-like growth factor 1 (IGF-1) has been associated with increased risk of atherosclerosis and atrial fibrillation in cross-sectional studies. Yet, prospective data linking IGF-1 levels to the development of ischemic stroke remain inconclusive. We examined prospectively the association between serum IGF-1 levels and incident ischemic stroke. Methods - We measured serum IGF-1 levels in 757 elderly individuals (mean age 79±5, 62{\%} women), free of prevalent stroke, from the Framingham original cohort participants at the 22nd examination cycle (1990-1994) and were followed up for the development of ischemic stroke. Cox models were used to relate IGF-1 levels to the risk for incident ischemic stroke, adjusted for potential confounders. Results - During a mean follow-up of 10.2 years, 99 individuals developed ischemic stroke. After adjustment for age, sex, and potential confounders, higher IGF-1 levels were associated with a lower risk of incident ischemic stroke, with subjects in the lowest quintile of IGF-1 levels having a 2.3-fold higher risk of incident ischemic stroke (95{\%} confidence interval, 1.09-5.06; P=0.03) as compared with those in the top quintile. We observed an effect modification by diabetes mellitus and waist-hip ratio for the association between IGF-1 and ischemic stroke (P<0.1). In subgroup analyses, the effects were restricted to subjects with diabetics and those in top waist-hip ratio quartile, in whom each standard deviation increase in IGF-1 was associated with a 61{\%} (hazard ratio, 0.39; 95{\%} confidence interval, 0.20-0.78; P=0.007) and 41{\%} (hazard ratio, 0.59; 95{\%} confidence interval, 0.37-0.95; P=0.031) lower risk of incident ischemic stroke, respectively. Conclusions - IGF-1 levels were inversely associated with ischemic stroke, especially among persons with insulin resistance.",
keywords = "atrial fibrillation, IGF-1, insulin resistance, ischemic stroke, risk",
author = "Hamidreza Saber and Himali, {Jayandra J.} and Beiser, {Alexa S.} and Ashkan Shoamanesh and Aleksandra Pikula and Ronenn Roubenoff and Romero, {Jose R.} and Kase, {Carlos S.} and Vasan, {Ramachandran S.} and Sudha Seshadri",
year = "2017",
month = "7",
day = "1",
doi = "10.1161/STROKEAHA.116.016563",
language = "English (US)",
volume = "48",
pages = "1760--1765",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "7",

}

TY - JOUR

T1 - Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke

AU - Saber, Hamidreza

AU - Himali, Jayandra J.

AU - Beiser, Alexa S.

AU - Shoamanesh, Ashkan

AU - Pikula, Aleksandra

AU - Roubenoff, Ronenn

AU - Romero, Jose R.

AU - Kase, Carlos S.

AU - Vasan, Ramachandran S.

AU - Seshadri, Sudha

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Background and Purpose - Low insulin-like growth factor 1 (IGF-1) has been associated with increased risk of atherosclerosis and atrial fibrillation in cross-sectional studies. Yet, prospective data linking IGF-1 levels to the development of ischemic stroke remain inconclusive. We examined prospectively the association between serum IGF-1 levels and incident ischemic stroke. Methods - We measured serum IGF-1 levels in 757 elderly individuals (mean age 79±5, 62% women), free of prevalent stroke, from the Framingham original cohort participants at the 22nd examination cycle (1990-1994) and were followed up for the development of ischemic stroke. Cox models were used to relate IGF-1 levels to the risk for incident ischemic stroke, adjusted for potential confounders. Results - During a mean follow-up of 10.2 years, 99 individuals developed ischemic stroke. After adjustment for age, sex, and potential confounders, higher IGF-1 levels were associated with a lower risk of incident ischemic stroke, with subjects in the lowest quintile of IGF-1 levels having a 2.3-fold higher risk of incident ischemic stroke (95% confidence interval, 1.09-5.06; P=0.03) as compared with those in the top quintile. We observed an effect modification by diabetes mellitus and waist-hip ratio for the association between IGF-1 and ischemic stroke (P<0.1). In subgroup analyses, the effects were restricted to subjects with diabetics and those in top waist-hip ratio quartile, in whom each standard deviation increase in IGF-1 was associated with a 61% (hazard ratio, 0.39; 95% confidence interval, 0.20-0.78; P=0.007) and 41% (hazard ratio, 0.59; 95% confidence interval, 0.37-0.95; P=0.031) lower risk of incident ischemic stroke, respectively. Conclusions - IGF-1 levels were inversely associated with ischemic stroke, especially among persons with insulin resistance.

AB - Background and Purpose - Low insulin-like growth factor 1 (IGF-1) has been associated with increased risk of atherosclerosis and atrial fibrillation in cross-sectional studies. Yet, prospective data linking IGF-1 levels to the development of ischemic stroke remain inconclusive. We examined prospectively the association between serum IGF-1 levels and incident ischemic stroke. Methods - We measured serum IGF-1 levels in 757 elderly individuals (mean age 79±5, 62% women), free of prevalent stroke, from the Framingham original cohort participants at the 22nd examination cycle (1990-1994) and were followed up for the development of ischemic stroke. Cox models were used to relate IGF-1 levels to the risk for incident ischemic stroke, adjusted for potential confounders. Results - During a mean follow-up of 10.2 years, 99 individuals developed ischemic stroke. After adjustment for age, sex, and potential confounders, higher IGF-1 levels were associated with a lower risk of incident ischemic stroke, with subjects in the lowest quintile of IGF-1 levels having a 2.3-fold higher risk of incident ischemic stroke (95% confidence interval, 1.09-5.06; P=0.03) as compared with those in the top quintile. We observed an effect modification by diabetes mellitus and waist-hip ratio for the association between IGF-1 and ischemic stroke (P<0.1). In subgroup analyses, the effects were restricted to subjects with diabetics and those in top waist-hip ratio quartile, in whom each standard deviation increase in IGF-1 was associated with a 61% (hazard ratio, 0.39; 95% confidence interval, 0.20-0.78; P=0.007) and 41% (hazard ratio, 0.59; 95% confidence interval, 0.37-0.95; P=0.031) lower risk of incident ischemic stroke, respectively. Conclusions - IGF-1 levels were inversely associated with ischemic stroke, especially among persons with insulin resistance.

KW - atrial fibrillation

KW - IGF-1

KW - insulin resistance

KW - ischemic stroke

KW - risk

UR - http://www.scopus.com/inward/record.url?scp=85020628937&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020628937&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.116.016563

DO - 10.1161/STROKEAHA.116.016563

M3 - Article

C2 - 28596451

AN - SCOPUS:85020628937

VL - 48

SP - 1760

EP - 1765

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 7

ER -