SERUM HIGH-DENSITY LIPOPROTEINS IN PERIPHERAL VASCULAR DISEASE

G. V.H. Bradby; A. J. Valente; K. W. Walton

doi:10.1016/S0140-6736(78)92038-X

SERUM HIGH-DENSITY LIPOPROTEINS IN PERIPHERAL VASCULAR DISEASE

G. V.H. Bradby, A. J. Valente, K. W. Walton

Medicine

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

High-density lipoprotein (H.D.L.) cholesterol has been measured by the 'Autoanalyzer', and apolipoproteins A-I, A-II, and B by an immunochemical method, in 100 patients with peripheral vascular disease (P.V.D.) and in 93 age and sex matched controls with an approximately similar prevalence of hyperlipidæmia. The patients with P.V.D. had significantly lower levels of the H.D.L. apolipoproteins (especially of apo A-I) than the controls. Further analysis of the data showed low H.D.L. levels to be related to the presence (but not to the severity) of the arterial disease and to be independent of concurrent hyperlipidæmia and smoking habits. The changes in H.D.L. apoproteins were not so clearly reflected by H.D.L.-cholesterol measurements in the same patients, possibly because of methodological reasons. It is therefore suggested that studies relating serum-H.D.L. to arterial disease may be more informative if both the lipid and protein portions of these lipoproteins are measured.

Original language	English (US)
Pages (from-to)	1271-1274
Number of pages	4
Journal	The Lancet
Volume	312
Issue number	8103
DOIs	https://doi.org/10.1016/S0140-6736(78)92038-X
State	Published - Dec 16 1978

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Medicine(all)

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title = "SERUM HIGH-DENSITY LIPOPROTEINS IN PERIPHERAL VASCULAR DISEASE",

abstract = "High-density lipoprotein (H.D.L.) cholesterol has been measured by the 'Autoanalyzer', and apolipoproteins A-I, A-II, and B by an immunochemical method, in 100 patients with peripheral vascular disease (P.V.D.) and in 93 age and sex matched controls with an approximately similar prevalence of hyperlipid{\ae}mia. The patients with P.V.D. had significantly lower levels of the H.D.L. apolipoproteins (especially of apo A-I) than the controls. Further analysis of the data showed low H.D.L. levels to be related to the presence (but not to the severity) of the arterial disease and to be independent of concurrent hyperlipid{\ae}mia and smoking habits. The changes in H.D.L. apoproteins were not so clearly reflected by H.D.L.-cholesterol measurements in the same patients, possibly because of methodological reasons. It is therefore suggested that studies relating serum-H.D.L. to arterial disease may be more informative if both the lipid and protein portions of these lipoproteins are measured.",

author = "Bradby, {G. V.H.} and Valente, {A. J.} and Walton, {K. W.}",

note = "Funding Information: We thank Prof. T. P. Whitehead and the staff of the Wolfson Labor- atories, Birmingham, for carrying out lipid measurements; and Prof&p.ound; G. Slaney and Prof. F. Ashton of the Department of Surgery, Univer- sity Birmingham, patients. J. supported by the of Medical Research for access Council to their and G. V. H. B. A. by the was British Heart Foundation. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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doi = "10.1016/S0140-6736(78)92038-X",

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N1 - Funding Information: We thank Prof. T. P. Whitehead and the staff of the Wolfson Labor- atories, Birmingham, for carrying out lipid measurements; and Prof&p.ound; G. Slaney and Prof. F. Ashton of the Department of Surgery, Univer- sity Birmingham, patients. J. supported by the of Medical Research for access Council to their and G. V. H. B. A. by the was British Heart Foundation. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.

PY - 1978/12/16

Y1 - 1978/12/16

N2 - High-density lipoprotein (H.D.L.) cholesterol has been measured by the 'Autoanalyzer', and apolipoproteins A-I, A-II, and B by an immunochemical method, in 100 patients with peripheral vascular disease (P.V.D.) and in 93 age and sex matched controls with an approximately similar prevalence of hyperlipidæmia. The patients with P.V.D. had significantly lower levels of the H.D.L. apolipoproteins (especially of apo A-I) than the controls. Further analysis of the data showed low H.D.L. levels to be related to the presence (but not to the severity) of the arterial disease and to be independent of concurrent hyperlipidæmia and smoking habits. The changes in H.D.L. apoproteins were not so clearly reflected by H.D.L.-cholesterol measurements in the same patients, possibly because of methodological reasons. It is therefore suggested that studies relating serum-H.D.L. to arterial disease may be more informative if both the lipid and protein portions of these lipoproteins are measured.

AB - High-density lipoprotein (H.D.L.) cholesterol has been measured by the 'Autoanalyzer', and apolipoproteins A-I, A-II, and B by an immunochemical method, in 100 patients with peripheral vascular disease (P.V.D.) and in 93 age and sex matched controls with an approximately similar prevalence of hyperlipidæmia. The patients with P.V.D. had significantly lower levels of the H.D.L. apolipoproteins (especially of apo A-I) than the controls. Further analysis of the data showed low H.D.L. levels to be related to the presence (but not to the severity) of the arterial disease and to be independent of concurrent hyperlipidæmia and smoking habits. The changes in H.D.L. apoproteins were not so clearly reflected by H.D.L.-cholesterol measurements in the same patients, possibly because of methodological reasons. It is therefore suggested that studies relating serum-H.D.L. to arterial disease may be more informative if both the lipid and protein portions of these lipoproteins are measured.

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SERUM HIGH-DENSITY LIPOPROTEINS IN PERIPHERAL VASCULAR DISEASE

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