SERUM HIGH-DENSITY LIPOPROTEINS IN PERIPHERAL VASCULAR DISEASE

G. V.H. Bradby; A. J. Valente; K. W. Walton

doi:10.1016/S0140-6736(78)92038-X

SERUM HIGH-DENSITY LIPOPROTEINS IN PERIPHERAL VASCULAR DISEASE

G. V.H. Bradby, A. J. Valente, K. W. Walton

Medicine

Research output: Contribution to journal › Article

84 Scopus citations

Abstract

High-density lipoprotein (H.D.L.) cholesterol has been measured by the 'Autoanalyzer', and apolipoproteins A-I, A-II, and B by an immunochemical method, in 100 patients with peripheral vascular disease (P.V.D.) and in 93 age and sex matched controls with an approximately similar prevalence of hyperlipidæmia. The patients with P.V.D. had significantly lower levels of the H.D.L. apolipoproteins (especially of apo A-I) than the controls. Further analysis of the data showed low H.D.L. levels to be related to the presence (but not to the severity) of the arterial disease and to be independent of concurrent hyperlipidæmia and smoking habits. The changes in H.D.L. apoproteins were not so clearly reflected by H.D.L.-cholesterol measurements in the same patients, possibly because of methodological reasons. It is therefore suggested that studies relating serum-H.D.L. to arterial disease may be more informative if both the lipid and protein portions of these lipoproteins are measured.

Original language	English (US)
Pages (from-to)	1271-1274
Number of pages	4
Journal	The Lancet
Volume	312
Issue number	8103
DOIs	https://doi.org/10.1016/S0140-6736(78)92038-X
Publication status	Published - Dec 16 1978

Fingerprint

ASJC Scopus subject areas

Medicine(all)

Cite this

Bradby, G. V. H., Valente, A. J., & Walton, K. W. (1978). SERUM HIGH-DENSITY LIPOPROTEINS IN PERIPHERAL VASCULAR DISEASE. The Lancet, 312(8103), 1271-1274. https://doi.org/10.1016/S0140-6736(78)92038-X

@article{914dd90c4ebe4db3853ee082489c40c4,

title = "SERUM HIGH-DENSITY LIPOPROTEINS IN PERIPHERAL VASCULAR DISEASE",

abstract = "High-density lipoprotein (H.D.L.) cholesterol has been measured by the 'Autoanalyzer', and apolipoproteins A-I, A-II, and B by an immunochemical method, in 100 patients with peripheral vascular disease (P.V.D.) and in 93 age and sex matched controls with an approximately similar prevalence of hyperlipid{\ae}mia. The patients with P.V.D. had significantly lower levels of the H.D.L. apolipoproteins (especially of apo A-I) than the controls. Further analysis of the data showed low H.D.L. levels to be related to the presence (but not to the severity) of the arterial disease and to be independent of concurrent hyperlipid{\ae}mia and smoking habits. The changes in H.D.L. apoproteins were not so clearly reflected by H.D.L.-cholesterol measurements in the same patients, possibly because of methodological reasons. It is therefore suggested that studies relating serum-H.D.L. to arterial disease may be more informative if both the lipid and protein portions of these lipoproteins are measured.",

author = "Bradby, {G. V.H.} and Valente, {A. J.} and Walton, {K. W.}",

year = "1978",

month = "12",

day = "16",

doi = "10.1016/S0140-6736(78)92038-X",

language = "English (US)",

volume = "312",

pages = "1271--1274",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "8103",

}

TY - JOUR

T1 - SERUM HIGH-DENSITY LIPOPROTEINS IN PERIPHERAL VASCULAR DISEASE

AU - Bradby, G. V.H.

AU - Valente, A. J.

AU - Walton, K. W.

PY - 1978/12/16

Y1 - 1978/12/16

N2 - High-density lipoprotein (H.D.L.) cholesterol has been measured by the 'Autoanalyzer', and apolipoproteins A-I, A-II, and B by an immunochemical method, in 100 patients with peripheral vascular disease (P.V.D.) and in 93 age and sex matched controls with an approximately similar prevalence of hyperlipidæmia. The patients with P.V.D. had significantly lower levels of the H.D.L. apolipoproteins (especially of apo A-I) than the controls. Further analysis of the data showed low H.D.L. levels to be related to the presence (but not to the severity) of the arterial disease and to be independent of concurrent hyperlipidæmia and smoking habits. The changes in H.D.L. apoproteins were not so clearly reflected by H.D.L.-cholesterol measurements in the same patients, possibly because of methodological reasons. It is therefore suggested that studies relating serum-H.D.L. to arterial disease may be more informative if both the lipid and protein portions of these lipoproteins are measured.

AB - High-density lipoprotein (H.D.L.) cholesterol has been measured by the 'Autoanalyzer', and apolipoproteins A-I, A-II, and B by an immunochemical method, in 100 patients with peripheral vascular disease (P.V.D.) and in 93 age and sex matched controls with an approximately similar prevalence of hyperlipidæmia. The patients with P.V.D. had significantly lower levels of the H.D.L. apolipoproteins (especially of apo A-I) than the controls. Further analysis of the data showed low H.D.L. levels to be related to the presence (but not to the severity) of the arterial disease and to be independent of concurrent hyperlipidæmia and smoking habits. The changes in H.D.L. apoproteins were not so clearly reflected by H.D.L.-cholesterol measurements in the same patients, possibly because of methodological reasons. It is therefore suggested that studies relating serum-H.D.L. to arterial disease may be more informative if both the lipid and protein portions of these lipoproteins are measured.

UR - http://www.scopus.com/inward/record.url?scp=0018242703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018242703&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(78)92038-X

DO - 10.1016/S0140-6736(78)92038-X

M3 - Article

C2 - 82779

AN - SCOPUS:0018242703

VL - 312

SP - 1271

EP - 1274

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8103

ER -

Access to Document

10.1016/S0140-6736(78)92038-X