TY - JOUR
T1 - Serum gentamicin levels in patients with post-cesarean endomyometritis
AU - Duff, Patrick
AU - Jorgensen, James H.
AU - Gibbs, Ronald S.
AU - Blancomd, Jorge D.
AU - Alexander, Gary
AU - Castaneda, Yolanda S.
PY - 1983/6
Y1 - 1983/6
N2 - Serum gentamicin levels were measured by agar diffusion bioassay in 38 patients undergoing treatment with clinda-mycin-gentamicin for post-cesarean endomyometritis. Patients received intravenous gentamicin in a dose of 1 mg/kg actual body weight every eight hours. All trough levels were less than lμg/ml. The mean 30-minute postinfusion level was 5.78 ± 2.43 μg/ml (mean ± SD). The range of postinfusion concentrations was 1 to 12 μg/ml. Postinfusion concentrations were less than 5 μg/ml in 13 patients, but none of these individuals experienced a clinical failure of antimicrobial therapy. There were no statistically significant differences in mean age, weight, hematocrit, serum creatinine, estimated creatinine clearance, or administered dose in patients with therapeutic gentamicin levels and patients with apparent subtherapeutic levels. The authors conclude that postinfusion gentamicin concentrations fluctuate widely in obstetric patients receiving 1 mg/kg/dose and that apparent subtherapeutic postinfusion levels still may be clinically efficacious, depending upon the antimicrobial susceptibility of the infecting microorganisms.
AB - Serum gentamicin levels were measured by agar diffusion bioassay in 38 patients undergoing treatment with clinda-mycin-gentamicin for post-cesarean endomyometritis. Patients received intravenous gentamicin in a dose of 1 mg/kg actual body weight every eight hours. All trough levels were less than lμg/ml. The mean 30-minute postinfusion level was 5.78 ± 2.43 μg/ml (mean ± SD). The range of postinfusion concentrations was 1 to 12 μg/ml. Postinfusion concentrations were less than 5 μg/ml in 13 patients, but none of these individuals experienced a clinical failure of antimicrobial therapy. There were no statistically significant differences in mean age, weight, hematocrit, serum creatinine, estimated creatinine clearance, or administered dose in patients with therapeutic gentamicin levels and patients with apparent subtherapeutic levels. The authors conclude that postinfusion gentamicin concentrations fluctuate widely in obstetric patients receiving 1 mg/kg/dose and that apparent subtherapeutic postinfusion levels still may be clinically efficacious, depending upon the antimicrobial susceptibility of the infecting microorganisms.
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M3 - Article
C2 - 6843931
AN - SCOPUS:0020586356
VL - 61
SP - 723
EP - 727
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology
SN - 0029-7844
IS - 6
ER -