Serum gentamicin levels in patients with post-cesarean endomyometritis

Patrick Duff, James H. Jorgensen, Ronald S. Gibbs, Jorge D. Blancomd, Gary Alexander, Yolanda S. Castaneda

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Serum gentamicin levels were measured by agar diffusion bioassay in 38 patients undergoing treatment with clinda-mycin-gentamicin for post-cesarean endomyometritis. Patients received intravenous gentamicin in a dose of 1 mg/kg actual body weight every eight hours. All trough levels were less than lμg/ml. The mean 30-minute postinfusion level was 5.78 ± 2.43 μg/ml (mean ± SD). The range of postinfusion concentrations was 1 to 12 μg/ml. Postinfusion concentrations were less than 5 μg/ml in 13 patients, but none of these individuals experienced a clinical failure of antimicrobial therapy. There were no statistically significant differences in mean age, weight, hematocrit, serum creatinine, estimated creatinine clearance, or administered dose in patients with therapeutic gentamicin levels and patients with apparent subtherapeutic levels. The authors conclude that postinfusion gentamicin concentrations fluctuate widely in obstetric patients receiving 1 mg/kg/dose and that apparent subtherapeutic postinfusion levels still may be clinically efficacious, depending upon the antimicrobial susceptibility of the infecting microorganisms.

Original languageEnglish (US)
Pages (from-to)723-727
Number of pages5
JournalObstetrics and Gynecology
Volume61
Issue number6
StatePublished - Jun 1983

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Serum gentamicin levels in patients with post-cesarean endomyometritis'. Together they form a unique fingerprint.

  • Cite this

    Duff, P., Jorgensen, J. H., Gibbs, R. S., Blancomd, J. D., Alexander, G., & Castaneda, Y. S. (1983). Serum gentamicin levels in patients with post-cesarean endomyometritis. Obstetrics and Gynecology, 61(6), 723-727.