Abstract
Serum gentamicin levels were measured by agar diffusion bioassay in 38 patients undergoing treatment with clindamycin-gentamicin for post-cesarean endomyometritis. Patients received intravenous gentamicin in a dose of 1 mg/kg actual body weight every eight hours. All trough levels were less than 1μg/ml. The mean 30-minute postinfusion level was 5.78 ± 2.43 μg/ml (mean ± SD). The range of postinfusion concentrations was 1 to 12 μg/ml. Postinfusion concentrations were less than 5 μg/ml in 13 patients, but none of these individuals experienced a clinical failure of antimicrobial therapy. There were no statistically significant differences in mean age, weight, hematocrit, serum creatinine, estimated creatinine clearance, or administered dose in patients with therapeutc gentamicin levels and patients with apparent subtherapeutic levels. The authors conclude that postinfusion gentamicin concentrations fluctuate widely in obstetric patients receiving 1 mg/kg/dose and that apparent subtherapeutic postinfusion levels still may be clinically efficacious, depending upon the antimicrobial susceptibility of the infecting microorganisms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 723-727 |
| Number of pages | 5 |
| Journal | Obstetrics and Gynecology |
| Volume | 61 |
| Issue number | 6 |
| State | Published - 1983 |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Serum gentamicin levels in patients with post-cesarean endomyometritis. / Duff, P.; Jorgensen, J. H.; Gibbs, R. S.; Blanco, J. D.; Alexander, G.; Castaneda, Y. S.
In: Obstetrics and Gynecology, Vol. 61, No. 6, 1983, p. 723-727.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum gentamicin levels in patients with post-cesarean endomyometritis
AU - Duff, P.
AU - Jorgensen, J. H.
AU - Gibbs, R. S.
AU - Blanco, J. D.
AU - Alexander, G.
AU - Castaneda, Y. S.
PY - 1983
Y1 - 1983
N2 - Serum gentamicin levels were measured by agar diffusion bioassay in 38 patients undergoing treatment with clindamycin-gentamicin for post-cesarean endomyometritis. Patients received intravenous gentamicin in a dose of 1 mg/kg actual body weight every eight hours. All trough levels were less than 1μg/ml. The mean 30-minute postinfusion level was 5.78 ± 2.43 μg/ml (mean ± SD). The range of postinfusion concentrations was 1 to 12 μg/ml. Postinfusion concentrations were less than 5 μg/ml in 13 patients, but none of these individuals experienced a clinical failure of antimicrobial therapy. There were no statistically significant differences in mean age, weight, hematocrit, serum creatinine, estimated creatinine clearance, or administered dose in patients with therapeutc gentamicin levels and patients with apparent subtherapeutic levels. The authors conclude that postinfusion gentamicin concentrations fluctuate widely in obstetric patients receiving 1 mg/kg/dose and that apparent subtherapeutic postinfusion levels still may be clinically efficacious, depending upon the antimicrobial susceptibility of the infecting microorganisms.
AB - Serum gentamicin levels were measured by agar diffusion bioassay in 38 patients undergoing treatment with clindamycin-gentamicin for post-cesarean endomyometritis. Patients received intravenous gentamicin in a dose of 1 mg/kg actual body weight every eight hours. All trough levels were less than 1μg/ml. The mean 30-minute postinfusion level was 5.78 ± 2.43 μg/ml (mean ± SD). The range of postinfusion concentrations was 1 to 12 μg/ml. Postinfusion concentrations were less than 5 μg/ml in 13 patients, but none of these individuals experienced a clinical failure of antimicrobial therapy. There were no statistically significant differences in mean age, weight, hematocrit, serum creatinine, estimated creatinine clearance, or administered dose in patients with therapeutc gentamicin levels and patients with apparent subtherapeutic levels. The authors conclude that postinfusion gentamicin concentrations fluctuate widely in obstetric patients receiving 1 mg/kg/dose and that apparent subtherapeutic postinfusion levels still may be clinically efficacious, depending upon the antimicrobial susceptibility of the infecting microorganisms.
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M3 - Article
C2 - 6843931
AN - SCOPUS:0020586356
VL - 61
SP - 723
EP - 727
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology
SN - 0029-7844
IS - 6
ER -