Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement-independent mechanism

Antonio L. Teixeira, Melissa M. Guimarães, Marco Aurélio Romano-Silva, Francisco Cardoso

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The proposed pathogenesis of Sydenham's chorea (SQ) is an autoantibody-mediated basal ganglia dysfunction. Our study has shown that incubation of PC12 cells with complement-inactivated serum from SC patients was associated with a significant increase in Ca2+ levels evoked by KCl stimulus (mean ± SEM, 341.0 ± 8.7% of fluorescence intensity, arbitrary units) when compared with incubation with control serum (313.8 ± 8.7% of fluorescence intensity, arbitrary units; P = 0.01). The increase in Ca2+ levels determined by SC patients sera correlated directly with the enzyme-linked immunosorbent assay optical density values for anti-basal ganglia antibodies. Our study supports the hypothesis that antibodies against basal ganglia in SC may cause their dysfunction.

Original languageEnglish (US)
Pages (from-to)843-845
Number of pages3
JournalMovement Disorders
Volume20
Issue number7
DOIs
StatePublished - Jul 2005
Externally publishedYes

Keywords

  • Antibasal ganglia antibodies
  • Ca
  • PC12 cells
  • Streptococcus
  • Sydenham's chorea

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Serum from Sydenham's chorea patients modifies intracellular calcium levels in PC12 cells by a complement-independent mechanism'. Together they form a unique fingerprint.

Cite this