Abstract
The proposed pathogenesis of Sydenham's chorea (SQ) is an autoantibody-mediated basal ganglia dysfunction. Our study has shown that incubation of PC12 cells with complement-inactivated serum from SC patients was associated with a significant increase in Ca2+ levels evoked by KCl stimulus (mean ± SEM, 341.0 ± 8.7% of fluorescence intensity, arbitrary units) when compared with incubation with control serum (313.8 ± 8.7% of fluorescence intensity, arbitrary units; P = 0.01). The increase in Ca2+ levels determined by SC patients sera correlated directly with the enzyme-linked immunosorbent assay optical density values for anti-basal ganglia antibodies. Our study supports the hypothesis that antibodies against basal ganglia in SC may cause their dysfunction.
Original language | English (US) |
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Pages (from-to) | 843-845 |
Number of pages | 3 |
Journal | Movement Disorders |
Volume | 20 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2005 |
Externally published | Yes |
Keywords
- Antibasal ganglia antibodies
- Ca
- PC12 cells
- Streptococcus
- Sydenham's chorea
ASJC Scopus subject areas
- Neurology
- Clinical Neurology