Serum dioxin, testosterone, and gonadotropins in veterans of operation ranch hand

Gary L. Henriksen, Joel E. Michalek, James A. Swaby, Alton J. Rahe

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


We studied whether exposure to Agent Orange and its contaminant, 2,3,7,8- tetrachlorodibenzo-p-dioxin (dioxin), during the Vietnam War is related to current testosterone, follicle-stimulating hormone, luteinizing hormone, or testicular abnormalities, sperm count, sperm abnormalities, or testicular volume. The index subjects were veterans of Operation Ranch Hand, the unit responsible for aerial herbicide spraying in Vietnam from 1962 to 1971. The referent cohort comprises Air Force veterans who served in Southeast Asia during the same period but were not involved with spraying herbicides. Referents were matched to Ranch Hands on dare of birth, race, and military occupation. We found no consistent or meaningful association between serum dioxin levels and any of these outcome variables.

Original languageEnglish (US)
Pages (from-to)352-357
Number of pages6
Issue number4
StatePublished - 1996


  • dioxin
  • gonadotropins
  • sperm

ASJC Scopus subject areas

  • Epidemiology


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