Serum dioxin and immunologic response in veterans of Operation Ranch Hand

Joel E Michalek, Norma S. Ketchum, Irene J. Check

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The authors studied immune response and exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin (dioxin) among veterans of Operation Ranch Hand, the US Air Force unit responsible for the aerial spraying of herbicides in Vietnam from 1962 to 1971. A comparison group of Air Force veterans who served in Southeast Asia but were not involved in spraying herbicides was included. The authors studied delayed-type hypersensitivity skin test responses to Candida albicans, mumps, Trichophyton, and a bacterial antigen made from lysed Staphylococcus aureus. Lymphocyte measurements included total lymphocyte counts; T-cell (CD3, CD4, CD5, and CD8), B-cell (CD20), and NK- cell (CD16 and CD56) subsets; and expression of the activation antigen CD25 on CD3 T cells. The authors quantitated the serum concentrations of immunoglobulin (Ig)A, IgG, and IgM; examined sera for the presence of monoclonal immunoglobulins (M proteins); and looked for a broad range of autoantibodies (rheumatoid factor, antinuclear antibody, smooth muscle autoantibody, mitochondrial autoantibody, parietal cell autoantibody, and thyroid microsomal autoantibodies). They measured the level of dioxin in 1987 or 1992, extrapolated the result to the time of service in Vietnam, and assigned each veteran to one of four exposure categories: Comparison and three Ranch Hand groups (Background, Low, or High). Overall, the authors found no evidence of a consistent relation between dioxin exposure category and immune system alteration.

Original languageEnglish (US)
Pages (from-to)1038-1046
Number of pages9
JournalAmerican Journal of Epidemiology
Volume149
Issue number11
StatePublished - Jun 1 1999
Externally publishedYes

Fingerprint

Dioxins
Veterans
Autoantibodies
Hand
Serum
Vietnam
Herbicides
Immunoglobulin M
Air
Interleukin-2 Receptor alpha Subunit
Bacterial Antigens
T-Lymphocytes
Mumps
Southeastern Asia
Trichophyton
Rheumatoid Factor
Antinuclear Antibodies
Delayed Hypersensitivity
Lymphocyte Count
Skin Tests

Keywords

  • Autoantibodies
  • Dioxins
  • Herbicides
  • Hypersensitivity, delayed
  • Immune system
  • Military personnel
  • Skin tests
  • Veterans

ASJC Scopus subject areas

  • Epidemiology

Cite this

Serum dioxin and immunologic response in veterans of Operation Ranch Hand. / Michalek, Joel E; Ketchum, Norma S.; Check, Irene J.

In: American Journal of Epidemiology, Vol. 149, No. 11, 01.06.1999, p. 1038-1046.

Research output: Contribution to journalArticle

Michalek, Joel E ; Ketchum, Norma S. ; Check, Irene J. / Serum dioxin and immunologic response in veterans of Operation Ranch Hand. In: American Journal of Epidemiology. 1999 ; Vol. 149, No. 11. pp. 1038-1046.
@article{de1fb4f069b442aab7836d96c91c7da8,
title = "Serum dioxin and immunologic response in veterans of Operation Ranch Hand",
abstract = "The authors studied immune response and exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin (dioxin) among veterans of Operation Ranch Hand, the US Air Force unit responsible for the aerial spraying of herbicides in Vietnam from 1962 to 1971. A comparison group of Air Force veterans who served in Southeast Asia but were not involved in spraying herbicides was included. The authors studied delayed-type hypersensitivity skin test responses to Candida albicans, mumps, Trichophyton, and a bacterial antigen made from lysed Staphylococcus aureus. Lymphocyte measurements included total lymphocyte counts; T-cell (CD3, CD4, CD5, and CD8), B-cell (CD20), and NK- cell (CD16 and CD56) subsets; and expression of the activation antigen CD25 on CD3 T cells. The authors quantitated the serum concentrations of immunoglobulin (Ig)A, IgG, and IgM; examined sera for the presence of monoclonal immunoglobulins (M proteins); and looked for a broad range of autoantibodies (rheumatoid factor, antinuclear antibody, smooth muscle autoantibody, mitochondrial autoantibody, parietal cell autoantibody, and thyroid microsomal autoantibodies). They measured the level of dioxin in 1987 or 1992, extrapolated the result to the time of service in Vietnam, and assigned each veteran to one of four exposure categories: Comparison and three Ranch Hand groups (Background, Low, or High). Overall, the authors found no evidence of a consistent relation between dioxin exposure category and immune system alteration.",
keywords = "Autoantibodies, Dioxins, Herbicides, Hypersensitivity, delayed, Immune system, Military personnel, Skin tests, Veterans",
author = "Michalek, {Joel E} and Ketchum, {Norma S.} and Check, {Irene J.}",
year = "1999",
month = "6",
day = "1",
language = "English (US)",
volume = "149",
pages = "1038--1046",
journal = "American Journal of Epidemiology",
issn = "0002-9262",
publisher = "Oxford University Press",
number = "11",

}

TY - JOUR

T1 - Serum dioxin and immunologic response in veterans of Operation Ranch Hand

AU - Michalek, Joel E

AU - Ketchum, Norma S.

AU - Check, Irene J.

PY - 1999/6/1

Y1 - 1999/6/1

N2 - The authors studied immune response and exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin (dioxin) among veterans of Operation Ranch Hand, the US Air Force unit responsible for the aerial spraying of herbicides in Vietnam from 1962 to 1971. A comparison group of Air Force veterans who served in Southeast Asia but were not involved in spraying herbicides was included. The authors studied delayed-type hypersensitivity skin test responses to Candida albicans, mumps, Trichophyton, and a bacterial antigen made from lysed Staphylococcus aureus. Lymphocyte measurements included total lymphocyte counts; T-cell (CD3, CD4, CD5, and CD8), B-cell (CD20), and NK- cell (CD16 and CD56) subsets; and expression of the activation antigen CD25 on CD3 T cells. The authors quantitated the serum concentrations of immunoglobulin (Ig)A, IgG, and IgM; examined sera for the presence of monoclonal immunoglobulins (M proteins); and looked for a broad range of autoantibodies (rheumatoid factor, antinuclear antibody, smooth muscle autoantibody, mitochondrial autoantibody, parietal cell autoantibody, and thyroid microsomal autoantibodies). They measured the level of dioxin in 1987 or 1992, extrapolated the result to the time of service in Vietnam, and assigned each veteran to one of four exposure categories: Comparison and three Ranch Hand groups (Background, Low, or High). Overall, the authors found no evidence of a consistent relation between dioxin exposure category and immune system alteration.

AB - The authors studied immune response and exposure to 2,3,7,8- tetrachlorodibenzo-p-dioxin (dioxin) among veterans of Operation Ranch Hand, the US Air Force unit responsible for the aerial spraying of herbicides in Vietnam from 1962 to 1971. A comparison group of Air Force veterans who served in Southeast Asia but were not involved in spraying herbicides was included. The authors studied delayed-type hypersensitivity skin test responses to Candida albicans, mumps, Trichophyton, and a bacterial antigen made from lysed Staphylococcus aureus. Lymphocyte measurements included total lymphocyte counts; T-cell (CD3, CD4, CD5, and CD8), B-cell (CD20), and NK- cell (CD16 and CD56) subsets; and expression of the activation antigen CD25 on CD3 T cells. The authors quantitated the serum concentrations of immunoglobulin (Ig)A, IgG, and IgM; examined sera for the presence of monoclonal immunoglobulins (M proteins); and looked for a broad range of autoantibodies (rheumatoid factor, antinuclear antibody, smooth muscle autoantibody, mitochondrial autoantibody, parietal cell autoantibody, and thyroid microsomal autoantibodies). They measured the level of dioxin in 1987 or 1992, extrapolated the result to the time of service in Vietnam, and assigned each veteran to one of four exposure categories: Comparison and three Ranch Hand groups (Background, Low, or High). Overall, the authors found no evidence of a consistent relation between dioxin exposure category and immune system alteration.

KW - Autoantibodies

KW - Dioxins

KW - Herbicides

KW - Hypersensitivity, delayed

KW - Immune system

KW - Military personnel

KW - Skin tests

KW - Veterans

UR - http://www.scopus.com/inward/record.url?scp=0033152570&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033152570&partnerID=8YFLogxK

M3 - Article

C2 - 10355380

AN - SCOPUS:0033152570

VL - 149

SP - 1038

EP - 1046

JO - American Journal of Epidemiology

JF - American Journal of Epidemiology

SN - 0002-9262

IS - 11

ER -