Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort study

Shah Ebrahim, Joohon Sung, Yun Mi Song, Robert L Ferrer, Debbie A. Lawlor, George Davey Smith

Research output: Contribution to journalArticle

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Abstract

Objective: To investigate risk factors, such as heavy alcohol consumption, that might explain any increased risk of haemorrhagic stroke associated with low blood cholesterol. Design: Prospective cohort study. Setting: Korea. Participants: 787 442 civil servants (661 700 men, 125 742 women) aged 30-64. Main outcome measures: Cardiovascular risk factors were assessed at biennial health check. Data on morbidity and mortality were ascertained from 1990 to 2001 using hospital admissions and mortality surveillance systems. Results: 6328 cases of ischaemic stroke (6021 men, 307 women), 3947 cases of haemorrhagic stroke (3748 men, 199 women), 3170 cases of undefined stroke (2902 men, 268 women), and 4417 cases of myocardial infarction (4305 men, 112 women) occurred. Ischaemic stroke and myocardial infarction were strongly and positively associated with blood cholesterol (hazard ratio per 1 mmol/1 cholesterol 1.20 (95% confidence interval 1.16 to 1.24) and 1.48 (1.43 to 1.53), respectively). Haemorrhagic stroke showed an inverse association in fully adjusted models (0.91, 0.87 to 0.95). This inverse association was confined to participants with hypertension. When stratified by concentration of γ glutamyl transferase (GGT), an indicator of alcohol consumption, the association was not seen in participants with low concentrations of GGT, and it was independent of hypertension in those with high concentrations of GGT (>80 U/l). Conclusions: High alcohol consumption may underlie the association between low blood cholesterol and increased risk of haemorrhagic stroke.

Original languageEnglish (US)
Pages (from-to)22-25
Number of pages4
JournalBritish Medical Journal
Volume333
Issue number7557
DOIs
StatePublished - Jul 1 2006

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Cohort Studies
Stroke
Myocardial Infarction
Cholesterol
Prospective Studies
Health
Serum
Alcohol Drinking
Hypertension
Korea
Transferases
Hospital Mortality
Outcome Assessment (Health Care)
Confidence Intervals
Morbidity
Mortality

ASJC Scopus subject areas

  • Medicine(all)

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Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction : Korean national health system prospective cohort study. / Ebrahim, Shah; Sung, Joohon; Song, Yun Mi; Ferrer, Robert L; Lawlor, Debbie A.; Smith, George Davey.

In: British Medical Journal, Vol. 333, No. 7557, 01.07.2006, p. 22-25.

Research output: Contribution to journalArticle

Ebrahim, Shah ; Sung, Joohon ; Song, Yun Mi ; Ferrer, Robert L ; Lawlor, Debbie A. ; Smith, George Davey. / Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction : Korean national health system prospective cohort study. In: British Medical Journal. 2006 ; Vol. 333, No. 7557. pp. 22-25.
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