Serum biomarkers associated with aging and neurodegeneration in common marmosets (Callithrix jacchus)

Kimberley A. Phillips, Matthew Lopez, Evelyn Bartling-John, Reagan Meredith, Anna Buteau, Addaline Alvarez, Corinna N. Ross

    Research output: Contribution to journalArticlepeer-review


    The common marmoset (Callithrix jacchus), a small South American monkey, is an important nonhuman primate model in the study of aging and age-related neurodegenerative disease, including Alzheimer's disease, Parkinson's disease, and related dementias. Thorough characterization of the wild type marmoset brain aging model, including biomarkers of aging and neural degeneration, will further the marmoset's utility in translational research. We measured serum concentration of four key biomarkers of neural degeneration [total tau (T-tau), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and ubiquitin C-terminal hydrolase-L1 (UCH-L1)] via single molecule array from 24 marmosets (female n = 13, male n = 11) ranging in age from 1.3 to 18.7 years. Aged marmosets (>7 years) had significantly higher GFAP, NfL, UCH-L1, and T-tau than adult marmosets. Sex differences were not detected for any of these biomarker concentrations. These data provide an important initial range of reference values for GFAP, NfL, T-tau, and UCH-L1 to evaluate aging and neural health in marmosets, as well as evaluation of therapeutics in clinical models of disease.

    Original languageEnglish (US)
    Article number137569
    JournalNeuroscience Letters
    StatePublished - Jan 10 2024


    • Biomarkers
    • Common marmoset
    • GFAP
    • Neurodegeneration
    • Neurofilament light
    • Tau
    • UCH-L1

    ASJC Scopus subject areas

    • General Neuroscience


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