TY - JOUR
T1 - Serum biomarkers associated with aging and neurodegeneration in common marmosets (Callithrix jacchus)
AU - Phillips, Kimberley A.
AU - Lopez, Matthew
AU - Bartling-John, Evelyn
AU - Meredith, Reagan
AU - Buteau, Anna
AU - Alvarez, Addaline
AU - Ross, Corinna N.
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2024/1/10
Y1 - 2024/1/10
N2 - The common marmoset (Callithrix jacchus), a small South American monkey, is an important nonhuman primate model in the study of aging and age-related neurodegenerative disease, including Alzheimer's disease, Parkinson's disease, and related dementias. Thorough characterization of the wild type marmoset brain aging model, including biomarkers of aging and neural degeneration, will further the marmoset's utility in translational research. We measured serum concentration of four key biomarkers of neural degeneration [total tau (T-tau), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and ubiquitin C-terminal hydrolase-L1 (UCH-L1)] via single molecule array from 24 marmosets (female n = 13, male n = 11) ranging in age from 1.3 to 18.7 years. Aged marmosets (>7 years) had significantly higher GFAP, NfL, UCH-L1, and T-tau than adult marmosets. Sex differences were not detected for any of these biomarker concentrations. These data provide an important initial range of reference values for GFAP, NfL, T-tau, and UCH-L1 to evaluate aging and neural health in marmosets, as well as evaluation of therapeutics in clinical models of disease.
AB - The common marmoset (Callithrix jacchus), a small South American monkey, is an important nonhuman primate model in the study of aging and age-related neurodegenerative disease, including Alzheimer's disease, Parkinson's disease, and related dementias. Thorough characterization of the wild type marmoset brain aging model, including biomarkers of aging and neural degeneration, will further the marmoset's utility in translational research. We measured serum concentration of four key biomarkers of neural degeneration [total tau (T-tau), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and ubiquitin C-terminal hydrolase-L1 (UCH-L1)] via single molecule array from 24 marmosets (female n = 13, male n = 11) ranging in age from 1.3 to 18.7 years. Aged marmosets (>7 years) had significantly higher GFAP, NfL, UCH-L1, and T-tau than adult marmosets. Sex differences were not detected for any of these biomarker concentrations. These data provide an important initial range of reference values for GFAP, NfL, T-tau, and UCH-L1 to evaluate aging and neural health in marmosets, as well as evaluation of therapeutics in clinical models of disease.
KW - Biomarkers
KW - Common marmoset
KW - GFAP
KW - Neurodegeneration
KW - Neurofilament light
KW - Tau
KW - UCH-L1
UR - http://www.scopus.com/inward/record.url?scp=85179034339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85179034339&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2023.137569
DO - 10.1016/j.neulet.2023.137569
M3 - Article
C2 - 38000775
AN - SCOPUS:85179034339
SN - 0304-3940
VL - 819
JO - Neuroscience Letters
JF - Neuroscience Letters
M1 - 137569
ER -