Abstract
Subjects with oral herpes lesions at the time of serum sampling had higher-efficiency antibody (higher proportion of neutralizing antibody as determined by plaque reduction, compared with total antibody as detected by radioimmunoassay) to herpes simplex virus type 1 (HSV-1) than did subjects with no lesions at the time of serum sampling. These higher-efficiency sera also had higher antibody titers to structural components of herpes simplex virus type 1 than did the low-efficiency sera. Absorption of high- and low-efficiency sera with purified herpes simplex virus type 1 particles removed all neutralizing antibody but not all antibody detected by radioimmunoassay. High-efficiency serum was depleted of more antibody to particulate antigen than was the low-efficiency serum, indicating that the high-efficiency serum contained a higher proportion of antibody to the virus particle.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 113-117 |
| Number of pages | 5 |
| Journal | Infection and immunity |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1980 |
| Externally published | Yes |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases