Serum and urine beta-2-microglobulin and lysozyme concentrations in transplant rejection.

J. L. Roberts, E. J. Lewis

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


We conclude that serum and urinary beta-2-microglobulin concentrations are useful in the diagnosis of acute and chronic renal transplant rejection. In acute transplant rejection, serum elevation in beta-2-microglobulins usually precede a rise in the serum creatinine. Increased urinary beta-2-microglobulin concentrations and elevated fractional excretion of beta-2-microglobulin occur in both acute and chronic transplant rejection. The finding of massive and sustained beta-2-microglobulinuria following acute rejection may herald recurrent clinical rejection episodes and eventual graft loss. Finally, serum and urine lysozyme levels appear to be less sensitive than the beta-2-microglobulins for diagnosing rejection and are often spuriously elevated in the presence of systemic or urinary tract infection.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalProceedings of the Clinical Dialysis and Transplant Forum
StatePublished - Dec 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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