Serum and urine beta-2-microglobulin and lysozyme concentrations in transplant rejection.

James Roberts, E. J. Lewis

Research output: Contribution to journalArticle

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Abstract

We conclude that serum and urinary beta-2-microglobulin concentrations are useful in the diagnosis of acute and chronic renal transplant rejection. In acute transplant rejection, serum elevation in beta-2-microglobulins usually precede a rise in the serum creatinine. Increased urinary beta-2-microglobulin concentrations and elevated fractional excretion of beta-2-microglobulin occur in both acute and chronic transplant rejection. The finding of massive and sustained beta-2-microglobulinuria following acute rejection may herald recurrent clinical rejection episodes and eventual graft loss. Finally, serum and urine lysozyme levels appear to be less sensitive than the beta-2-microglobulins for diagnosing rejection and are often spuriously elevated in the presence of systemic or urinary tract infection.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalProceedings of the Clinical Dialysis and Transplant Forum
Volume9
StatePublished - 1979
Externally publishedYes

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beta 2-Microglobulin
Graft Rejection
Muramidase
Urine
Serum
Urinary Tract Infections
Creatinine
Transplants
Kidney

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Serum and urine beta-2-microglobulin and lysozyme concentrations in transplant rejection. / Roberts, James; Lewis, E. J.

In: Proceedings of the Clinical Dialysis and Transplant Forum, Vol. 9, 1979, p. 145-149.

Research output: Contribution to journalArticle

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