Abstract
We conclude that serum and urinary beta-2-microglobulin concentrations are useful in the diagnosis of acute and chronic renal transplant rejection. In acute transplant rejection, serum elevation in beta-2-microglobulins usually precede a rise in the serum creatinine. Increased urinary beta-2-microglobulin concentrations and elevated fractional excretion of beta-2-microglobulin occur in both acute and chronic transplant rejection. The finding of massive and sustained beta-2-microglobulinuria following acute rejection may herald recurrent clinical rejection episodes and eventual graft loss. Finally, serum and urine lysozyme levels appear to be less sensitive than the beta-2-microglobulins for diagnosing rejection and are often spuriously elevated in the presence of systemic or urinary tract infection.
Original language | English (US) |
---|---|
Pages (from-to) | 145-149 |
Number of pages | 5 |
Journal | Proceedings of the Clinical Dialysis and Transplant Forum |
Volume | 9 |
State | Published - Dec 1 1979 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)