Abstract
We conclude that serum and urinary beta-2-microglobulin concentrations are useful in the diagnosis of acute and chronic renal transplant rejection. In acute transplant rejection, serum elevation in beta-2-microglobulins usually precede a rise in the serum creatinine. Increased urinary beta-2-microglobulin concentrations and elevated fractional excretion of beta-2-microglobulin occur in both acute and chronic transplant rejection. The finding of massive and sustained beta-2-microglobulinuria following acute rejection may herald recurrent clinical rejection episodes and eventual graft loss. Finally, serum and urine lysozyme levels appear to be less sensitive than the beta-2-microglobulins for diagnosing rejection and are often spuriously elevated in the presence of systemic or urinary tract infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 145-149 |
| Number of pages | 5 |
| Journal | Proceedings of the Clinical Dialysis and Transplant Forum |
| Volume | 9 |
| State | Published - 1979 |
| Externally published | Yes |
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- Medicine(all)
Cite this
Serum and urine beta-2-microglobulin and lysozyme concentrations in transplant rejection. / Roberts, James; Lewis, E. J.
In: Proceedings of the Clinical Dialysis and Transplant Forum, Vol. 9, 1979, p. 145-149.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum and urine beta-2-microglobulin and lysozyme concentrations in transplant rejection.
AU - Roberts, James
AU - Lewis, E. J.
PY - 1979
Y1 - 1979
N2 - We conclude that serum and urinary beta-2-microglobulin concentrations are useful in the diagnosis of acute and chronic renal transplant rejection. In acute transplant rejection, serum elevation in beta-2-microglobulins usually precede a rise in the serum creatinine. Increased urinary beta-2-microglobulin concentrations and elevated fractional excretion of beta-2-microglobulin occur in both acute and chronic transplant rejection. The finding of massive and sustained beta-2-microglobulinuria following acute rejection may herald recurrent clinical rejection episodes and eventual graft loss. Finally, serum and urine lysozyme levels appear to be less sensitive than the beta-2-microglobulins for diagnosing rejection and are often spuriously elevated in the presence of systemic or urinary tract infection.
AB - We conclude that serum and urinary beta-2-microglobulin concentrations are useful in the diagnosis of acute and chronic renal transplant rejection. In acute transplant rejection, serum elevation in beta-2-microglobulins usually precede a rise in the serum creatinine. Increased urinary beta-2-microglobulin concentrations and elevated fractional excretion of beta-2-microglobulin occur in both acute and chronic transplant rejection. The finding of massive and sustained beta-2-microglobulinuria following acute rejection may herald recurrent clinical rejection episodes and eventual graft loss. Finally, serum and urine lysozyme levels appear to be less sensitive than the beta-2-microglobulins for diagnosing rejection and are often spuriously elevated in the presence of systemic or urinary tract infection.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018607341&partnerID=8YFLogxK
M3 - Article
C2 - 95329
AN - SCOPUS:0018607341
VL - 9
SP - 145
EP - 149
JO - Proceedings of the Clinical Dialysis and Transplant Forum
JF - Proceedings of the Clinical Dialysis and Transplant Forum
SN - 0094-6044
ER -