Serum and rectal mucosal zinc levels in acute and chronic diarrhea.

H. P. Sachdev, Naveen K Mittal, H. S. Yadav

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Serum and rectal mucosal zinc content was estimated in children (6-18 months old) with acute diarrhea (Group I: n = 50), chronic diarrhea (Group II: n = 25), extraintestinal infections (Group III: n = 15) and apparently healthy controls (Group IV: n = 20). The sex and nutritional status of various groups was comparable. The mean serum and tissue zinc levels in acute (p less than 0.001) and chronic (p less than 0.05 for serum; p less than 0.001 for tissue) diarrhea groups were significantly lower than healthy and infected controls. Group II had significantly lower (p less than 0.001) serum and rectal zinc content in comparison to Group I. There was a significant negative correlation between serum zinc and diarrheal duration (r = 0.5676; p less than 0.001). Repeat estimation at discharge in 38 patients (25 in Group I, 13 in Group II) revealed a significant reduction in both tissue and serum zinc and only tissue zinc in acute and chronic diarrhea, respectively. A total of 23 patients (16 in Group I, and 7 in Group II) were evaluated 2 weeks after discharge. After discharge, at recovery there was no alteration in serum zinc, but tissue zinc was marginally higher (p greater than 0.05). It is concluded that zinc depletion occurs in diarrhea, more so in the chronic state; with the continuation of diarrhea, depletion progresses; and there is a tendency for repletion during convalescence.

Original languageEnglish (US)
Pages (from-to)125-133
Number of pages9
JournalIndian Pediatrics
Volume27
Issue number2
StatePublished - Feb 1990
Externally publishedYes

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Zinc
Diarrhea
Serum
Nutritional Status
Control Groups
Infection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Sachdev, H. P., Mittal, N. K., & Yadav, H. S. (1990). Serum and rectal mucosal zinc levels in acute and chronic diarrhea. Indian Pediatrics, 27(2), 125-133.

Serum and rectal mucosal zinc levels in acute and chronic diarrhea. / Sachdev, H. P.; Mittal, Naveen K; Yadav, H. S.

In: Indian Pediatrics, Vol. 27, No. 2, 02.1990, p. 125-133.

Research output: Contribution to journalArticle

Sachdev, HP, Mittal, NK & Yadav, HS 1990, 'Serum and rectal mucosal zinc levels in acute and chronic diarrhea.', Indian Pediatrics, vol. 27, no. 2, pp. 125-133.
Sachdev HP, Mittal NK, Yadav HS. Serum and rectal mucosal zinc levels in acute and chronic diarrhea. Indian Pediatrics. 1990 Feb;27(2):125-133.
Sachdev, H. P. ; Mittal, Naveen K ; Yadav, H. S. / Serum and rectal mucosal zinc levels in acute and chronic diarrhea. In: Indian Pediatrics. 1990 ; Vol. 27, No. 2. pp. 125-133.
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