Serum and cerebral spinal fluid levels of chemokines and Th2 cytokines in Schistosoma mansoni myeloradiculopathy

S. R. Sousa-Pereira; A. L. Teixeira; L. C.S. Silva; A. L.S. Souza; C. M. Antunes; M. M. Teixeira; J. R. Lambertucci

doi:10.1111/j.1365-3024.2006.00896.x

Serum and cerebral spinal fluid levels of chemokines and Th2 cytokines in Schistosoma mansoni myeloradiculopathy

S. R. Sousa-Pereira, A. L. Teixeira, L. C.S. Silva, A. L.S. Souza, C. M. Antunes, M. M. Teixeira, J. R. Lambertucci

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Schistosomal myeloradiculopathy (SMR) is the most common neurological form of Schistosoma mansoni infection. In this study we investigated the expression of chemokines and Th2 cytokines in serum and cerebral spinal fluid (CSF) of SMR patients. SMR patients presented increased serum levels of CCL11/eotaxin and CCL24/eotaxin-2 when compared to controls. SMR patients also had higher levels of IL-13 in CSF. Thus, SMR patients present enhancement of both IL-13 and CCR3 acting chemokines, both of which may facilitate the expression of a Th2 response and Th2-dependent damage to the spinal cord. As this cytokine is responsible for promoting Th2 responses, this finding is in accordance to the view that Th2 cells are important in the immunological process against the S. mansoni.

Original language	English (US)
Pages (from-to)	473-478
Number of pages	6
Journal	Parasite Immunology
Volume	28
Issue number	9
DOIs	https://doi.org/10.1111/j.1365-3024.2006.00896.x
State	Published - Sep 2006
Externally published	Yes

Keywords

Chemokines
Cytokines
Myeloradiculopathy
Neuroschistosomiasis
Schistosomiasis

ASJC Scopus subject areas

Parasitology
Immunology

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10.1111/j.1365-3024.2006.00896.x

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title = "Serum and cerebral spinal fluid levels of chemokines and Th2 cytokines in Schistosoma mansoni myeloradiculopathy",

abstract = "Schistosomal myeloradiculopathy (SMR) is the most common neurological form of Schistosoma mansoni infection. In this study we investigated the expression of chemokines and Th2 cytokines in serum and cerebral spinal fluid (CSF) of SMR patients. SMR patients presented increased serum levels of CCL11/eotaxin and CCL24/eotaxin-2 when compared to controls. SMR patients also had higher levels of IL-13 in CSF. Thus, SMR patients present enhancement of both IL-13 and CCR3 acting chemokines, both of which may facilitate the expression of a Th2 response and Th2-dependent damage to the spinal cord. As this cytokine is responsible for promoting Th2 responses, this finding is in accordance to the view that Th2 cells are important in the immunological process against the S. mansoni.",

keywords = "Chemokines, Cytokines, Myeloradiculopathy, Neuroschistosomiasis, Schistosomiasis",

author = "Sousa-Pereira, {S. R.} and Teixeira, {A. L.} and Silva, {L. C.S.} and Souza, {A. L.S.} and Antunes, {C. M.} and Teixeira, {M. M.} and Lambertucci, {J. R.}",

year = "2006",

month = sep,

doi = "10.1111/j.1365-3024.2006.00896.x",

language = "English (US)",

volume = "28",

pages = "473--478",

journal = "Parasite Immunology",

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T1 - Serum and cerebral spinal fluid levels of chemokines and Th2 cytokines in Schistosoma mansoni myeloradiculopathy

AU - Sousa-Pereira, S. R.

AU - Teixeira, A. L.

AU - Silva, L. C.S.

AU - Souza, A. L.S.

AU - Antunes, C. M.

AU - Teixeira, M. M.

AU - Lambertucci, J. R.

PY - 2006/9

Y1 - 2006/9

N2 - Schistosomal myeloradiculopathy (SMR) is the most common neurological form of Schistosoma mansoni infection. In this study we investigated the expression of chemokines and Th2 cytokines in serum and cerebral spinal fluid (CSF) of SMR patients. SMR patients presented increased serum levels of CCL11/eotaxin and CCL24/eotaxin-2 when compared to controls. SMR patients also had higher levels of IL-13 in CSF. Thus, SMR patients present enhancement of both IL-13 and CCR3 acting chemokines, both of which may facilitate the expression of a Th2 response and Th2-dependent damage to the spinal cord. As this cytokine is responsible for promoting Th2 responses, this finding is in accordance to the view that Th2 cells are important in the immunological process against the S. mansoni.

AB - Schistosomal myeloradiculopathy (SMR) is the most common neurological form of Schistosoma mansoni infection. In this study we investigated the expression of chemokines and Th2 cytokines in serum and cerebral spinal fluid (CSF) of SMR patients. SMR patients presented increased serum levels of CCL11/eotaxin and CCL24/eotaxin-2 when compared to controls. SMR patients also had higher levels of IL-13 in CSF. Thus, SMR patients present enhancement of both IL-13 and CCR3 acting chemokines, both of which may facilitate the expression of a Th2 response and Th2-dependent damage to the spinal cord. As this cytokine is responsible for promoting Th2 responses, this finding is in accordance to the view that Th2 cells are important in the immunological process against the S. mansoni.

KW - Chemokines

KW - Cytokines

KW - Myeloradiculopathy

KW - Neuroschistosomiasis

KW - Schistosomiasis

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AN - SCOPUS:33747309064

SN - 0141-9838

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SP - 473

EP - 478

JO - Parasite Immunology

JF - Parasite Immunology

IS - 9

ER -

Serum and cerebral spinal fluid levels of chemokines and Th2 cytokines in Schistosoma mansoni myeloradiculopathy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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