Serum Amyloid P Component (SAP)-like Protein from Botryllid Ascidians Provides a Clue to Amyloid Function

V. L. Scofield, L. Puntambekar, S. F. Schluter, D. R. Coombe

Research output: Contribution to journalArticle

5 Scopus citations


The HA-1 lectin isolated from Botrylloides leachii has an amino acid composition similar to that of mammalian serum amyloid protein (SAP). SAP is a universal component of mammalian amyloid deposits. Like SAP, HA-1 has a disc ultrastructure, and antibody to HA-1 binds both (a) to amyloidlike fibers deposited between rejected Botrylloides colonies and (b) to cerebral amyloid deposits in Alzheimer’s disease brains. Deposition of protochordate amyloid within rejection sites and surrounding fouling organisms implies that these fibers function as barriers to allogeneic and infectious challenge. Similarly, mammalian amyloid may also function to contain inflammatory lesions and to limit the spread of certain infections. Pathological amyloidotic conditions in humans, such as Alzheimer’s disease, may result from unregulated expression of this primitive encapsulation response.

Original languageEnglish (US)
Pages (from-to)67-84
Number of pages18
JournalDevelopmental Immunology
Issue number1
StatePublished - Jan 1 1992



  • HA-1 lectin
  • SAP
  • amyloid
  • pentraxin
  • protochordate

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology

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