Serum γ-glutamyl transferase and risk of heart failure in the community

Ravi Dhingra, Philimon Gona, Thomas J. Wang, Caroline S. Fox, Ralph B. Dagostino, Ramachandran S. Vasan

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Objective: To examine the association of serum γ-glutamyltransferase (GGT) with incident heart failure. Methods and Results: We related serum GGT to the incidence of heart failure in 3544 (mean age, 44.5 years; 1833 women and 1711 men) Framingham Study participants who were free of heart failure and myocardial infarction. On follow-up (mean, 23.6 years), 188 participants (77 women) developed new-onset heart failure. In multivariable Cox proportional hazards regression models adjusting for standard risk factors and alcohol consumption as time-varying covariates (updated every 4 years), each SD increase in log-GGT was associated with a 1.39-fold risk of heart failure (95% CI, 1.20 to 1.62). The linearity of the association was confirmed by multivariable- adjusted splines, and the relations remained robust on additional adjustment for hepatic aminotransferases and C-reactive protein. Participants with a serum GGT level at the median or greater had a 1.71-fold risk of heart failure (95% CI, 1.21 to 2.41) compared with individuals with GGT concentrations less than the median. GGT marginally increased the model C-statistic from 0.85 to 0.86 but improved the risk reclassification modestly (net reclassification index, 5.7%; P=0.01). Conclusion: In this prospective study of a large community-based sample, higher serum GGT concentrations within the "normal" range were associated with greater risk of heart failure and incrementally improved prediction of heart failure risk.

Original languageEnglish (US)
Pages (from-to)1855-1860
Number of pages6
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number9
StatePublished - Sep 2010
Externally publishedYes


  • -glutamyl transferase
  • epidemiology
  • heart failure
  • oxidative stress γ
  • risk factors

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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