Serotonin(2A) receptor modulation of D1 dopamine receptor-mediated grooming behavior

J. M. Scalzitti, L. S. Cervera, C. Smith, J. G. Hensler

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

We have previously observed that intracerebroventricular infusion of a 5-HT(2A) receptor antisense oligonucleotide for 8 days results in an increase in cortical 5-HT(2A) receptor sites and an increase in central 5-HT(2A) receptor function as measured by quantitation of 5-HT(2A) receptor-mediated headshake behavior (28). Because lesioning serotonergic neurons or chronic administration of 5-HT(2A) receptor antagonists does not result in an increase in 5-HT(2A) receptor density or function in the brain, we have taken advantage of this unique upregulation of 5-HT(2A) receptors following 5-HT(2A) receptor antisense oligonucleotide infusion to study the modulation of D1 receptor-mediated behaviors by 5-HT(2A) receptors. Grooming behavior, elicited by acute injection of SKF 38393, was attenuated after chronic ICV infusion of a 5-HT(2A) receptor antisense oligonucleotide. There was also a reduction in vacuous chewing behavior induced by SKF 38393, which did not reach statistical significance. Other oral behaviors (i.e., tongue protrusions and gnawing at the cage bottom) were not attenuated. An increase in the density of cortical, as well as striatal 5-HT(2A) receptor sites was observed following chronic antisense oligonucleotide administration. There was no change in striatal D1 dopamine receptors following 5-HT(2A) receptor antisense oligonucleotide administration. SKF 38393-induced grooming behavior was also attenuated in naive rats pretreated acutely with the 5-HT2 receptor agonist DOI. These results suggest a role for the 5-HT(2A) receptor in the modulation of D1 receptor function. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)279-284
Number of pages6
JournalPharmacology Biochemistry and Behavior
Volume63
Issue number2
DOIs
StatePublished - Jun 1999

Keywords

  • 5-HT(2A) receptors
  • Antisense oligonucleotide
  • D dopamine receptors
  • Grooming behavior
  • Vacuous chewing

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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