Serotonin selective reuptake inhibitor drug interactions and the cytochrome P450 system

Larry Ereshefsky, Cara Riesenman, Y. W.Francis Lam

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations

Abstract

The article focuses on the effects of the serotonin selective reuptake inhibitors (SSRIs) on specific drug metabolizing isoenzymes: CYP2D6, CYP3A3/4, CYPIA2, CYP2C9, and CYP2C19. Both in vitro and in vivo data regarding the inhibition potential of the SSRIs at each of these isoenzyme systems are reviewed. In general, the magnitude of the in vivo interactions between the SSRIs and substrates for these isoenzyme systems mirrors to a large extent their in vitro inhibitory potencies. However, in vitro work is limited owing to pharmacokinetic considerations, the effect of metabolites on the isoenzymes, and the likelihood that several isoenzymes are co-responsible for the metabolism of a substrate.

Original languageEnglish (US)
Pages (from-to)17-25
Number of pages9
JournalJournal of Clinical Psychiatry
Volume57
Issue numberSUPPL. 8
StatePublished - Sep 5 1996

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint

Dive into the research topics of 'Serotonin selective reuptake inhibitor drug interactions and the cytochrome P450 system'. Together they form a unique fingerprint.

Cite this