Serotonin-Mediated Increase in Cytosolic [Ca++] in Platelets of Risperidone-Treated Schizophrenia Patients

Larry Ereshefsky, Cara Riesenman, Janet E. True, Martin Javors

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Stimulating the platelet 5HT2 receptor generates the second messenger IPS, and results in an increase in cytosolic [Ca++] ([Ca++]cyt). Platelets from risperidone-treated patients would be expected to respond less effectively, as measured by decreased [Ca++]cyt, after 5HT2 receptor stimulation. We report the data on 6 risperidone-treated patients and 6 normal controls evaluated at our site using the Fura-2 method for determining platelet [Ca++]cyt. Data analysis was performed by unpaired two-tailed Student's f-test. No significant differences between groups were found for ED50 5HT-stimulated [Ca++]cyt (ED50 5HT Δ [Ca++]cyt). Significant differences were found for maximal change [Ca++]cyt (Max Δ [Ca++]cyt) between risperidone-treated patients and normal controls (p=.03). These preliminary data suggest that measurement of 5HT-stimulated changes in platelet cytosolic [Ca++] might be a useful marker for in vivo risperidone inhibition of 5HT2 function.

Original languageEnglish (US)
Pages (from-to)101-106
Number of pages6
JournalPsychopharmacology bulletin
Volume32
Issue number1
StatePublished - Dec 1 1996

Keywords

  • 5HT
  • Calcium
  • Platelet
  • Risperidone
  • Serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)

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