Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate

William P. Clarke, Michael De Vivo, Sheryl G. Beck, Saul Maayani, Joseph Goldfarb

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Activation of the serotonin1A receptor decreases CA1 population spike amplitude and inhibits forskolin-stimulated adenylate cyclase in rat hippocampus. Pretreatment of rats with pertussis toxin blocked both responses. Because the electrophysiological and biochemical responses to serotonin were correlated after pertussis toxin treatment, we conclude that both responses are mediated by a common regulatory protein, presumably Gi.

Original languageEnglish (US)
Pages (from-to)357-361
Number of pages5
JournalBrain Research
Volume410
Issue number2
DOIs
StatePublished - May 5 1987
Externally publishedYes

Keywords

  • Adenylate cyclase
  • G protein
  • Hippocampus
  • Pertussis toxin
  • Population spike
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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