Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate

William P. Clarke; Michael De Vivo; Sheryl G. Beck; Saul Maayani; Joseph Goldfarb

doi:10.1016/0006-8993(87)90338-6

Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate

William P. Clarke, Michael De Vivo, Sheryl G. Beck, Saul Maayani, Joseph Goldfarb

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Activation of the serotonin_1A receptor decreases CA₁ population spike amplitude and inhibits forskolin-stimulated adenylate cyclase in rat hippocampus. Pretreatment of rats with pertussis toxin blocked both responses. Because the electrophysiological and biochemical responses to serotonin were correlated after pertussis toxin treatment, we conclude that both responses are mediated by a common regulatory protein, presumably G_i.

Original language	English (US)
Pages (from-to)	357-361
Number of pages	5
Journal	Brain Research
Volume	410
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(87)90338-6
State	Published - May 5 1987
Externally published	Yes

Keywords

Adenylate cyclase
G protein
Hippocampus
Pertussis toxin
Population spike
Serotonin

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(87)90338-6

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title = "Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate",

abstract = "Activation of the serotonin1A receptor decreases CA1 population spike amplitude and inhibits forskolin-stimulated adenylate cyclase in rat hippocampus. Pretreatment of rats with pertussis toxin blocked both responses. Because the electrophysiological and biochemical responses to serotonin were correlated after pertussis toxin treatment, we conclude that both responses are mediated by a common regulatory protein, presumably Gi.",

keywords = "Adenylate cyclase, G protein, Hippocampus, Pertussis toxin, Population spike, Serotonin",

author = "Clarke, {William P.} and {De Vivo}, Michael and Beck, {Sheryl G.} and Saul Maayani and Joseph Goldfarb",

note = "Funding Information: This work was supported by NIH postdoctoral Training Grant DA-07135. a Pharmaceutical Manufacturers Association Foundation fellowship to M.D.V., and Grants DA-01875 from the National Institute on Drug Abuse. GM-34852 from the National Institute of General Medical Sciences. and MH-41917 from the National Institute of Mental Health. Data analyses were performed on the PROPHET Computer System, a national resource supported by the Biochemical Research Technology Program. Division of Research Resources. National Institutes of Health.",

year = "1987",

month = may,

day = "5",

doi = "10.1016/0006-8993(87)90338-6",

language = "English (US)",

volume = "410",

pages = "357--361",

journal = "Brain Research",

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TY - JOUR

T1 - Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate

AU - Clarke, William P.

AU - De Vivo, Michael

AU - Beck, Sheryl G.

AU - Maayani, Saul

AU - Goldfarb, Joseph

N1 - Funding Information: This work was supported by NIH postdoctoral Training Grant DA-07135. a Pharmaceutical Manufacturers Association Foundation fellowship to M.D.V., and Grants DA-01875 from the National Institute on Drug Abuse. GM-34852 from the National Institute of General Medical Sciences. and MH-41917 from the National Institute of Mental Health. Data analyses were performed on the PROPHET Computer System, a national resource supported by the Biochemical Research Technology Program. Division of Research Resources. National Institutes of Health.

PY - 1987/5/5

Y1 - 1987/5/5

N2 - Activation of the serotonin1A receptor decreases CA1 population spike amplitude and inhibits forskolin-stimulated adenylate cyclase in rat hippocampus. Pretreatment of rats with pertussis toxin blocked both responses. Because the electrophysiological and biochemical responses to serotonin were correlated after pertussis toxin treatment, we conclude that both responses are mediated by a common regulatory protein, presumably Gi.

AB - Activation of the serotonin1A receptor decreases CA1 population spike amplitude and inhibits forskolin-stimulated adenylate cyclase in rat hippocampus. Pretreatment of rats with pertussis toxin blocked both responses. Because the electrophysiological and biochemical responses to serotonin were correlated after pertussis toxin treatment, we conclude that both responses are mediated by a common regulatory protein, presumably Gi.

KW - Adenylate cyclase

KW - G protein

KW - Hippocampus

KW - Pertussis toxin

KW - Population spike

KW - Serotonin

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ER -

Serotonin decreases population spike amplitude in hippocampal cells through a pertussis toxin substrate

Abstract

Keywords

ASJC Scopus subject areas

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