Serotonergic neuromodulation of peripheral nociceptors

Dayna R. Loyd; Michael A. Henry; Kenneth M. Hargreaves

doi:10.1016/j.semcdb.2012.09.002

Serotonergic neuromodulation of peripheral nociceptors

Dayna R. Loyd, Michael A. Henry, Kenneth M. Hargreaves

Department of Endodontics

Research output: Contribution to journal › Review article › peer-review

42 Scopus citations

Abstract

Nociception, the encoding and processing of noxious environmental stimuli by sensory neurons, functions to protect an organism from bodily damage. Activation of the terminal endings of certain sensory neurons, termed nociceptors, triggers a train of impulses to neurons in the spinal cord. Signals are integrated and processed in the dorsal spinal cord and then projected to the brain where they elicit the perception of pain. A number of neuromodulators that can affect nociceptors are released in the periphery during the inflammation that follows an initial injury. Serotonin (5-HT) is a one such proinflammatory mediator. This review discusses our current understanding of the neuromodulatory role of 5-HT, and specifically how this monoamine activates and sensitizes nociceptors. Potential therapeutic targets to treat pain are described.

Original language	English (US)
Pages (from-to)	51-57
Number of pages	7
Journal	Seminars in Cell and Developmental Biology
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.semcdb.2012.09.002
State	Published - Jan 2013

Keywords

5-HT
Nociception
Pain
Review
Serotonin
TRPV1

ASJC Scopus subject areas

Cell Biology
Developmental Biology

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10.1016/j.semcdb.2012.09.002

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AB - Nociception, the encoding and processing of noxious environmental stimuli by sensory neurons, functions to protect an organism from bodily damage. Activation of the terminal endings of certain sensory neurons, termed nociceptors, triggers a train of impulses to neurons in the spinal cord. Signals are integrated and processed in the dorsal spinal cord and then projected to the brain where they elicit the perception of pain. A number of neuromodulators that can affect nociceptors are released in the periphery during the inflammation that follows an initial injury. Serotonin (5-HT) is a one such proinflammatory mediator. This review discusses our current understanding of the neuromodulatory role of 5-HT, and specifically how this monoamine activates and sensitizes nociceptors. Potential therapeutic targets to treat pain are described.

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Serotonergic neuromodulation of peripheral nociceptors

Abstract

Keywords

ASJC Scopus subject areas

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