Serological analysis of the repertoire of human cancer antigens and autoantigens

E. P. Koroleva, M. A. Lagarkova, S. V. Khlgatian, Yu V. Shebzukhov, A. A. Mescheryakov, M. R. Lichinitser, S. A. Nedospasov, D. V. Kuprash

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The spectrum of human antigens allows a monitoring of various pathological processes such as autoimmune disorders and tumorigenesis. Serological analysis of cDNA expression libraries (SEREX) is now used to search for new cancer-associated antigens, which are potential diagnostic markers or targets for immunotherapy of cancer. The results obtained for several solid tumors are reviewed. Groups of antigens detectable by SEREX, causes of immunogenicity of autoantigens, and prospective implication of antigens in diagnostics and monitoring of cancer are discussed.

Original languageEnglish (US)
Pages (from-to)191-195
Number of pages5
JournalMolecular Biology
Issue number2
StatePublished - Mar 2004
Externally publishedYes


  • Autoantigens
  • Cancer immunodiagnostics
  • Expression libraries
  • cDNA

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology


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