TY - JOUR
T1 - Serial measurement of the circulating levels of tumour necrosis factor and its soluble receptors 1 and 2 for monitoring leprosy patients during multidrug treatment
AU - Costa, Rosane Dias
AU - Mendonça, Vanessa Amaral
AU - Soriani, Frederico Marianetti
AU - Lyon, Sandra
AU - Penido, Rachel Adriana
AU - Dias, Ana Maria Duarte Costa
AU - Costa, Marina Dias
AU - Terra, Fabio de Souza
AU - Teixeira, Mauro Martins
AU - Antunes, Carlos Mauricio de Figueiredo
AU - Teixeira, Antonio Lúcio
PY - 2013
Y1 - 2013
N2 - Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host response to the aetiologic agent, Mycobacterium leprae. The induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, primarily through the action of cytokines. The purpose of the present study was to evaluate the serum levels of tumour necrosis factor (TNF)-α and its soluble receptors (sTNF-R1 and sTNF-R2) in leprosy patients at different stages of multidrug treatment (MDT) in comparison with non-infected individuals and to determine their role as putative biomarkers of the severity of leprosy or the treatment response. ELISA was used to measure the levels of these molecules in 30 healthy controls and 37 leprosy patients at the time of diagnosis and during and after MDT. Our results showed increases in the serum levels of TNF-α and sTNF-R2 in infected individuals in comparison with controls. The levels of TNF-α, but not sTNF-R2, decreased with treatment. The current results corroborate previous reports of elevated serum levels of TNF-α in leprosy and suggest a role for sTNF-R2 in the control of this cytokine during MDT.
AB - Leprosy is an infectious and contagious spectral disease accompanied by a series of immunological events triggered by the host response to the aetiologic agent, Mycobacterium leprae. The induction and maintenance of the immune/inflammatory response in leprosy are linked to multiple cell interactions and soluble factors, primarily through the action of cytokines. The purpose of the present study was to evaluate the serum levels of tumour necrosis factor (TNF)-α and its soluble receptors (sTNF-R1 and sTNF-R2) in leprosy patients at different stages of multidrug treatment (MDT) in comparison with non-infected individuals and to determine their role as putative biomarkers of the severity of leprosy or the treatment response. ELISA was used to measure the levels of these molecules in 30 healthy controls and 37 leprosy patients at the time of diagnosis and during and after MDT. Our results showed increases in the serum levels of TNF-α and sTNF-R2 in infected individuals in comparison with controls. The levels of TNF-α, but not sTNF-R2, decreased with treatment. The current results corroborate previous reports of elevated serum levels of TNF-α in leprosy and suggest a role for sTNF-R2 in the control of this cytokine during MDT.
KW - Leprosy
KW - STNF-R1
KW - STNF-R2
KW - TNF-α
UR - http://www.scopus.com/inward/record.url?scp=84890373889&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890373889&partnerID=8YFLogxK
U2 - 10.1590/0074-0276130240
DO - 10.1590/0074-0276130240
M3 - Article
C2 - 24402158
AN - SCOPUS:84890373889
SN - 0074-0276
VL - 108
SP - 1051
EP - 1056
JO - Memorias do Instituto Oswaldo Cruz
JF - Memorias do Instituto Oswaldo Cruz
IS - 8
ER -