Sequential studies on the pathophysiology of glycerol-induced acute renal failure

H. John Reineck, Gerald J. O'Connor, Meyer D. Lifschitz, Jay H. Stein

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The role of volume depletion and renal ischemia in the development of renal functional impairment in glycerol-induced ARF is not clear. This study was designed to evaluate the role of volume depletion in this model by determining the hemodynamic and functional alterations which occur between 3 and 18 hr after glycerol administration and the reversibility of these changes in response to Ringer loading. Three hours after glycerol, CIn and RBF, measured by flowmeter, were reduced 70% and 52%, respectively, in comparison with control values. FeNa was 0.04%. Ringer loading increased CIn to 103% and RBF to 93% of control values. Qualitatively similar results were found 6 hr after glycerol. At 18 hr, CIn and RBF were 47% of control values. After Ringer loading, RBF rose to 100% of control. The response of CIn, however, was a function of the baseline FeNa. CIn increased substantially in rats with low FeNa but changed only slightly in animals in which this parameter was increased. These studies indicate that the early reduction in the CIn is dependent upon the fall in RBF. At 12 and 18 hr, however, the fall in CIn is not blood flow-dependent, and a second mechanism must be operative. FeNa seems to be a reliable index of the functional status of a given animal.

Original languageEnglish (US)
Pages (from-to)356-362
Number of pages7
JournalJournal of Laboratory and Clinical Medicine
Issue number2
StatePublished - 1980
Externally publishedYes


  • (C)
  • acute renal failure
  • ARF
  • FeNa
  • fractional excretion of sodium
  • GFR
  • glomerular filtration rate
  • inulin clearance
  • RBF
  • renal blood flow

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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