Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a guinea pig model of invasive aspergillosis

William R. Kirkpatrick; Brent J. Coco; Thomas F. Patterson

doi:10.1128/AAC.50.4.1567-1569.2006

Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a guinea pig model of invasive aspergillosis

William R. Kirkpatrick, Brent J. Coco, Thomas F. Patterson

Medicine

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

We evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.

Original language	English (US)
Pages (from-to)	1567-1569
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	50
Issue number	4
DOIs	https://doi.org/10.1128/AAC.50.4.1567-1569.2006
State	Published - Apr 2006

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "We evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.",

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