Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a guinea pig model of invasive aspergillosis

William R. Kirkpatrick, Brent J. Coco, Thomas F. Patterson

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

We evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.

Original languageEnglish (US)
Pages (from-to)1567-1569
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume50
Issue number4
DOIs
StatePublished - Apr 2006

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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