TY - JOUR
T1 - Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a guinea pig model of invasive aspergillosis
AU - Kirkpatrick, William R.
AU - Coco, Brent J.
AU - Patterson, Thomas F.
PY - 2006/4
Y1 - 2006/4
N2 - We evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.
AB - We evaluated combinations of voriconazole (VRC) and liposomal amphotericin B (L-AMB) in a guinea pig invasive aspergillosis model. Simultaneous VRC and L-AMB was most effective, although VRC monotherapy was also effective. These regimens as well as sequential L-AMB followed by VRC were more effective than L-AMB alone or VRC followed by L-AMB.
UR - http://www.scopus.com/inward/record.url?scp=33645754951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645754951&partnerID=8YFLogxK
U2 - 10.1128/AAC.50.4.1567-1569.2006
DO - 10.1128/AAC.50.4.1567-1569.2006
M3 - Article
C2 - 16569887
AN - SCOPUS:33645754951
SN - 0066-4804
VL - 50
SP - 1567
EP - 1569
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 4
ER -