Sequentiell alternierende Chemotherapie nicht-seminomatöser Hodentumoren mit Velbe/Bleomycin und Adriamycin/Cisplatin - I. Ergebnisse einer randomisierten Studie bei 71 Patienten mit pulmonaler Metastasierung (Stadium IV)

Translated title of the contribution: Sequential combination chemotherapy with vinblastine/bleomycin and adriamycin/Cis-Dichlorodiammineplatinum (II) in Non-seminomatous Testicular Cancer - I. Results of a prospective randomized phase III-study with 71 patients with disseminated disease (stage IV)

M. E. Scheulen, M. Higi, R. B. Schilcher, C. R. Meier, S. Seeber, C. G. Schmidt

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

74 patients with disseminated non-seminomatous testicular cancer were randomly entered on a prospective sequential combination chemotherapy regimen with mandatory crossover, consisting of either vinblastine/bleomycin or adriamycin/cis-dichlorodiammineplatinum (II) (DDP) as initial therapy. Independent of the randomization the overall remission rate in 71 evaluable patients was 89% including 54% complete remissions. 35% of the patients remained disease-free at 2+ to 28+ months with a median of 12 months. By additional surgical removal of residual pulmonary metastases in two patients the complete remission rate was increased to 40/71 (56%), and the number of patients with no evidence of disease to 27/71 (38%). According to the life-table method the two-years survival rates were 63% for complete responders and 29% for all other patients, which was significantly lower. 53 patients (75%) were alive at 3 to 28 months with a median of 9 months. Additional advanced abdominal disease, initially elevated β-HCG and LDH and extension of pulmonary disease were of significant negative influence on the prognosis. The evaluation of single chemotherapy courses revealed equal efficacy of both combinations. However, response to adriamycin/DDP occurred in 46% of the courses, when vinblastine/bleomycin had failed, while response to vinblastine/bleomycin occurred only in 21% of the courses when adriamycin/DDP had failed. Thus different patterns of cross-resistance between these alternative regimens may exist.

Translated title of the contributionSequential combination chemotherapy with vinblastine/bleomycin and adriamycin/Cis-Dichlorodiammineplatinum (II) in Non-seminomatous Testicular Cancer - I. Results of a prospective randomized phase III-study with 71 patients with disseminated disease (stage IV)
Original languageGerman
Pages (from-to)811-821
Number of pages11
JournalKlinische Wochenschrift
Volume58
Issue number16
DOIs
StatePublished - Aug 1 1980
Externally publishedYes

Keywords

  • Combination chemotherapy
  • Cross-resistance
  • Prognosis
  • Stage IV
  • Testicular neoplasms

ASJC Scopus subject areas

  • Medicine(all)

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