Sequence and expression of mRNAs encoding the α1 and α2 subunits of a DHP-sensitive calcium channel

Steven B. Ellis, Mark E. Williams, Nancy R. Ways, Robert Brenner, Alan H. Sharp, Albert T. Leung, Kevin P. Campbell, Edward McKenna, Walter J. Koch, Anna Hui, Arnold Schwartz, Michael M. Harpold

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Abstract

Complementary DNAs were isolated and used to deduce the primary structures of the α1, and α2 subunits of the dihydropyridine-sensitive, voltage-dependent calcium channel from rabbit skeletal muscle. The α1 subunit, which contains putative binding sites for calcium antagonists, is a hydrophobic protein with a sequence that is consistent with multiple transmembrane domains and shows structural and sequence homology with other voltage-dependent ion channels. In contrast, the α2 subunit is a hydrophilic protein without homology to other known protein sequences. Nucleic acid hybridization studies suggest that the α1 and α2 subunit mRNAs are expressed differentially in a tissue-specific manner and that there is a family of genes encoding additional calcium channel subtypes.

Original languageEnglish (US)
Pages (from-to)1661-1664
Number of pages4
JournalScience
Volume241
Issue number4873
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

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ASJC Scopus subject areas

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Cite this

Ellis, S. B., Williams, M. E., Ways, N. R., Brenner, R., Sharp, A. H., Leung, A. T., Campbell, K. P., McKenna, E., Koch, W. J., Hui, A., Schwartz, A., & Harpold, M. M. (1988). Sequence and expression of mRNAs encoding the α1 and α2 subunits of a DHP-sensitive calcium channel. Science, 241(4873), 1661-1664. https://doi.org/10.1126/science.2458626