Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

Henrique Borges da Silva; Changwei Peng; Haiguang Wang; Kelsey M. Wanhainen; Chaoyu Ma; Sharon Lopez; Alexander Khoruts; Nu Zhang; Stephen C. Jameson

doi:10.1016/j.immuni.2020.06.010

Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8⁺ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

Henrique Borges da Silva
, Changwei Peng
, Haiguang Wang
, Kelsey M. Wanhainen
, Chaoyu Ma
, Sharon Lopez
, Alexander Khoruts
, Nu Zhang
, Stephen C. Jameson

Department of Microbiology, Immunology & Molecular Genetics

Research output: Contribution to journal › Article › peer-review

114 Scopus citations

Abstract

Borges da Silva et al. report that the extracellular ATP receptor P2RX7 promotes generation of virus-specific tissue-resident memory (Trm) CD8⁺ T cells through induction of the TGF-β signaling pathway. Furthermore, long-term maintenance of Trm cells relies on continuous P2RX7 signaling.

Original language	English (US)
Pages (from-to)	158-171.e6
Journal	Immunity
Volume	53
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2020.06.010
State	Published - Jul 14 2020

Keywords

P2RX7
TGF-β
eATP
memory CD8 T cells
non-lymphoid tissue

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

Access to Document

10.1016/j.immuni.2020.06.010

Cite this

@article{596c1e13baf242ffaab542a6138ba8aa,

title = "Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β",

abstract = "Borges da Silva et al. report that the extracellular ATP receptor P2RX7 promotes generation of virus-specific tissue-resident memory (Trm) CD8+ T cells through induction of the TGF-β signaling pathway. Furthermore, long-term maintenance of Trm cells relies on continuous P2RX7 signaling.",

keywords = "P2RX7, TGF-β, eATP, memory CD8 T cells, non-lymphoid tissue",

author = "\{Borges da Silva\}, Henrique and Changwei Peng and Haiguang Wang and Wanhainen, \{Kelsey M.\} and Chaoyu Ma and Sharon Lopez and Alexander Khoruts and Nu Zhang and Jameson, \{Stephen C.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = jul,

day = "14",

doi = "10.1016/j.immuni.2020.06.010",

language = "English (US)",

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journal = "Immunity",

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T1 - Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

AU - Borges da Silva, Henrique

AU - Peng, Changwei

AU - Wang, Haiguang

AU - Wanhainen, Kelsey M.

AU - Ma, Chaoyu

AU - Lopez, Sharon

AU - Khoruts, Alexander

AU - Zhang, Nu

AU - Jameson, Stephen C.

PY - 2020/7/14

Y1 - 2020/7/14

N2 - Borges da Silva et al. report that the extracellular ATP receptor P2RX7 promotes generation of virus-specific tissue-resident memory (Trm) CD8+ T cells through induction of the TGF-β signaling pathway. Furthermore, long-term maintenance of Trm cells relies on continuous P2RX7 signaling.

AB - Borges da Silva et al. report that the extracellular ATP receptor P2RX7 promotes generation of virus-specific tissue-resident memory (Trm) CD8+ T cells through induction of the TGF-β signaling pathway. Furthermore, long-term maintenance of Trm cells relies on continuous P2RX7 signaling.

KW - P2RX7

KW - TGF-β

KW - eATP

KW - memory CD8 T cells

KW - non-lymphoid tissue

UR - https://www.scopus.com/pages/publications/85087772631

UR - https://www.scopus.com/pages/publications/85087772631#tab=citedBy

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DO - 10.1016/j.immuni.2020.06.010

M3 - Article

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AN - SCOPUS:85087772631

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