Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

Henrique Borges da Silva, Changwei Peng, Haiguang Wang, Kelsey M. Wanhainen, Chaoyu Ma, Sharon Lopez, Alexander Khoruts, Nu Zhang, Stephen C. Jameson

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Borges da Silva et al. report that the extracellular ATP receptor P2RX7 promotes generation of virus-specific tissue-resident memory (Trm) CD8+ T cells through induction of the TGF-β signaling pathway. Furthermore, long-term maintenance of Trm cells relies on continuous P2RX7 signaling.

Original languageEnglish (US)
Pages (from-to)158-171.e6
JournalImmunity
Volume53
Issue number1
DOIs
StatePublished - Jul 14 2020

Keywords

  • P2RX7
  • TGF-β
  • eATP
  • memory CD8 T cells
  • non-lymphoid tissue

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Borges da Silva, H., Peng, C., Wang, H., Wanhainen, K. M., Ma, C., Lopez, S., Khoruts, A., Zhang, N., & Jameson, S. C. (2020). Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β. Immunity, 53(1), 158-171.e6. https://doi.org/10.1016/j.immuni.2020.06.010