Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice

Rui Hua Xiang, Albert R. Davalos, Charles H. Hensel, Xiao Jun Zhou, Christin Tse, Susan L. Naylor

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

Loss of heterozygosity on human chromosome 3p21.3 is a frequent occurrence in many tumor types. In a previous study, our laboratory demonstrated that an 80-kb P1 clone from chromosome 3 suppresses the tumorigenicity of the mouse fibrosarcoma cell line A9. Two cDNAs corresponding to genes encoded on this P1 clone, semaphorin 3F (SEMA3F) and N23, were tested for their effects on in vitro and in vivo growth characteristics after transfection into mouse A9 cells. Transfection of SEMA3F cDNA resulted in complete loss of tumorigenicity in nude mice, whereas transfection of N23 had no effect. Moreover, SEMA3F also functioned to block apoptosis of transfected A9 cells treated with Taxol or Adriamycin. The human ovarian adenocarcinoma cell line HEY showed a similar result as A9 cells, but the small cell lung cancer line GLC45 was unaffected by expression of SEMA3F.

Original languageEnglish (US)
Pages (from-to)2637-2643
Number of pages7
JournalCancer Research
Volume62
Issue number9
StatePublished - May 1 2002

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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