Semaphorin 3B and 3F Single Nucleotide Polymorphisms are Associated With Prostate Cancer Risk and Poor Prognosis

Joke Beuten, Dawn Garcia, Timothy C. Brand, Xin He, Ivana Balic, Edith Canby-Hagino, Dean A. Troyer, Jacques Baillargeon, Javier Hernandez, Ian M. Thompson, Robin J Leach, Susan L. Naylor

Research output: Contribution to journalArticle

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Abstract

Purpose: SEMA3B and SEMA3F are 2 closely related genes lying 80 kb apart on chromosome 3 that have been shown to suppress tumor formation in vivo and in vitro. Each gene has a single nucleotide polymorphism that results in a nonsynonymous coding change, rs2071203 (SEMA3B) and rs1046956 (SEMA3F), as well as noncoding single nucleotide polymorphisms. Materials and Methods: We performed a case-control study of 789 prostate cancer cases and 907 controls from 3 races/ethnicities to determine possible associations of 10 variants with prostate cancer risk or prognosis. Results: The risk of prostate cancer increased more than 2-fold in Hispanic men with TT alleles at rs2071203 in SEMA3B and with CC alleles for rs2072054 at the 5′ end of SEMA3F (OR 2.13, 95% CI 1.12-4.04, p = 0.02 and OR 2.55, 95% CI 1.34-4.84, p = 0.0045, respectively). These 2 single nucleotide polymorphisms were also associated with a poor prognosis in Hispanic men (2.71 and 3.48-fold increased risk). A frequent G-C-G-G-A-T-C-C-T-G haplotype encompassing 10 SNPs was associated with an increased risk of prostate cancer and poor prognosis in Hispanic samples (OR 2.72, 95% CI 1.20-6.12, p = 0.016 and OR 3.32, 95% CI 1.21-9.10, p = 0.02). In nonHispanic white men the T-C-G-A-A-T-C-C haplotype was associated with a high Gleason score (OR 1.44, 95% CI 1.06-1.96, p = 0.021). Conclusions: These data indicate that polymorphisms in SEMA3B and SEMA3F are associated with prostate cancer risk and poor prognosis in Hispanic and nonHispanic white men.

Original languageEnglish (US)
Pages (from-to)1614-1620
Number of pages7
JournalJournal of Urology
Volume182
Issue number4 SUPPL.
DOIs
StatePublished - Oct 2009

Fingerprint

Semaphorins
Single Nucleotide Polymorphism
Prostatic Neoplasms
Hispanic Americans
Haplotypes
Alleles
Chromosomes, Human, Pair 3
Neoplasm Grading
Genes
Case-Control Studies
Neoplasms

Keywords

  • continental population groups
  • polymorphism
  • prostate
  • prostatic neoplasms
  • semaphorins
  • single nucleotide

ASJC Scopus subject areas

  • Urology

Cite this

Beuten, J., Garcia, D., Brand, T. C., He, X., Balic, I., Canby-Hagino, E., ... Naylor, S. L. (2009). Semaphorin 3B and 3F Single Nucleotide Polymorphisms are Associated With Prostate Cancer Risk and Poor Prognosis. Journal of Urology, 182(4 SUPPL.), 1614-1620. https://doi.org/10.1016/j.juro.2009.06.016

Semaphorin 3B and 3F Single Nucleotide Polymorphisms are Associated With Prostate Cancer Risk and Poor Prognosis. / Beuten, Joke; Garcia, Dawn; Brand, Timothy C.; He, Xin; Balic, Ivana; Canby-Hagino, Edith; Troyer, Dean A.; Baillargeon, Jacques; Hernandez, Javier; Thompson, Ian M.; Leach, Robin J; Naylor, Susan L.

In: Journal of Urology, Vol. 182, No. 4 SUPPL., 10.2009, p. 1614-1620.

Research output: Contribution to journalArticle

Beuten, J, Garcia, D, Brand, TC, He, X, Balic, I, Canby-Hagino, E, Troyer, DA, Baillargeon, J, Hernandez, J, Thompson, IM, Leach, RJ & Naylor, SL 2009, 'Semaphorin 3B and 3F Single Nucleotide Polymorphisms are Associated With Prostate Cancer Risk and Poor Prognosis', Journal of Urology, vol. 182, no. 4 SUPPL., pp. 1614-1620. https://doi.org/10.1016/j.juro.2009.06.016
Beuten, Joke ; Garcia, Dawn ; Brand, Timothy C. ; He, Xin ; Balic, Ivana ; Canby-Hagino, Edith ; Troyer, Dean A. ; Baillargeon, Jacques ; Hernandez, Javier ; Thompson, Ian M. ; Leach, Robin J ; Naylor, Susan L. / Semaphorin 3B and 3F Single Nucleotide Polymorphisms are Associated With Prostate Cancer Risk and Poor Prognosis. In: Journal of Urology. 2009 ; Vol. 182, No. 4 SUPPL. pp. 1614-1620.
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abstract = "Purpose: SEMA3B and SEMA3F are 2 closely related genes lying 80 kb apart on chromosome 3 that have been shown to suppress tumor formation in vivo and in vitro. Each gene has a single nucleotide polymorphism that results in a nonsynonymous coding change, rs2071203 (SEMA3B) and rs1046956 (SEMA3F), as well as noncoding single nucleotide polymorphisms. Materials and Methods: We performed a case-control study of 789 prostate cancer cases and 907 controls from 3 races/ethnicities to determine possible associations of 10 variants with prostate cancer risk or prognosis. Results: The risk of prostate cancer increased more than 2-fold in Hispanic men with TT alleles at rs2071203 in SEMA3B and with CC alleles for rs2072054 at the 5′ end of SEMA3F (OR 2.13, 95{\%} CI 1.12-4.04, p = 0.02 and OR 2.55, 95{\%} CI 1.34-4.84, p = 0.0045, respectively). These 2 single nucleotide polymorphisms were also associated with a poor prognosis in Hispanic men (2.71 and 3.48-fold increased risk). A frequent G-C-G-G-A-T-C-C-T-G haplotype encompassing 10 SNPs was associated with an increased risk of prostate cancer and poor prognosis in Hispanic samples (OR 2.72, 95{\%} CI 1.20-6.12, p = 0.016 and OR 3.32, 95{\%} CI 1.21-9.10, p = 0.02). In nonHispanic white men the T-C-G-A-A-T-C-C haplotype was associated with a high Gleason score (OR 1.44, 95{\%} CI 1.06-1.96, p = 0.021). Conclusions: These data indicate that polymorphisms in SEMA3B and SEMA3F are associated with prostate cancer risk and poor prognosis in Hispanic and nonHispanic white men.",
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author = "Joke Beuten and Dawn Garcia and Brand, {Timothy C.} and Xin He and Ivana Balic and Edith Canby-Hagino and Troyer, {Dean A.} and Jacques Baillargeon and Javier Hernandez and Thompson, {Ian M.} and Leach, {Robin J} and Naylor, {Susan L.}",
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T1 - Semaphorin 3B and 3F Single Nucleotide Polymorphisms are Associated With Prostate Cancer Risk and Poor Prognosis

AU - Beuten, Joke

AU - Garcia, Dawn

AU - Brand, Timothy C.

AU - He, Xin

AU - Balic, Ivana

AU - Canby-Hagino, Edith

AU - Troyer, Dean A.

AU - Baillargeon, Jacques

AU - Hernandez, Javier

AU - Thompson, Ian M.

AU - Leach, Robin J

AU - Naylor, Susan L.

PY - 2009/10

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N2 - Purpose: SEMA3B and SEMA3F are 2 closely related genes lying 80 kb apart on chromosome 3 that have been shown to suppress tumor formation in vivo and in vitro. Each gene has a single nucleotide polymorphism that results in a nonsynonymous coding change, rs2071203 (SEMA3B) and rs1046956 (SEMA3F), as well as noncoding single nucleotide polymorphisms. Materials and Methods: We performed a case-control study of 789 prostate cancer cases and 907 controls from 3 races/ethnicities to determine possible associations of 10 variants with prostate cancer risk or prognosis. Results: The risk of prostate cancer increased more than 2-fold in Hispanic men with TT alleles at rs2071203 in SEMA3B and with CC alleles for rs2072054 at the 5′ end of SEMA3F (OR 2.13, 95% CI 1.12-4.04, p = 0.02 and OR 2.55, 95% CI 1.34-4.84, p = 0.0045, respectively). These 2 single nucleotide polymorphisms were also associated with a poor prognosis in Hispanic men (2.71 and 3.48-fold increased risk). A frequent G-C-G-G-A-T-C-C-T-G haplotype encompassing 10 SNPs was associated with an increased risk of prostate cancer and poor prognosis in Hispanic samples (OR 2.72, 95% CI 1.20-6.12, p = 0.016 and OR 3.32, 95% CI 1.21-9.10, p = 0.02). In nonHispanic white men the T-C-G-A-A-T-C-C haplotype was associated with a high Gleason score (OR 1.44, 95% CI 1.06-1.96, p = 0.021). Conclusions: These data indicate that polymorphisms in SEMA3B and SEMA3F are associated with prostate cancer risk and poor prognosis in Hispanic and nonHispanic white men.

AB - Purpose: SEMA3B and SEMA3F are 2 closely related genes lying 80 kb apart on chromosome 3 that have been shown to suppress tumor formation in vivo and in vitro. Each gene has a single nucleotide polymorphism that results in a nonsynonymous coding change, rs2071203 (SEMA3B) and rs1046956 (SEMA3F), as well as noncoding single nucleotide polymorphisms. Materials and Methods: We performed a case-control study of 789 prostate cancer cases and 907 controls from 3 races/ethnicities to determine possible associations of 10 variants with prostate cancer risk or prognosis. Results: The risk of prostate cancer increased more than 2-fold in Hispanic men with TT alleles at rs2071203 in SEMA3B and with CC alleles for rs2072054 at the 5′ end of SEMA3F (OR 2.13, 95% CI 1.12-4.04, p = 0.02 and OR 2.55, 95% CI 1.34-4.84, p = 0.0045, respectively). These 2 single nucleotide polymorphisms were also associated with a poor prognosis in Hispanic men (2.71 and 3.48-fold increased risk). A frequent G-C-G-G-A-T-C-C-T-G haplotype encompassing 10 SNPs was associated with an increased risk of prostate cancer and poor prognosis in Hispanic samples (OR 2.72, 95% CI 1.20-6.12, p = 0.016 and OR 3.32, 95% CI 1.21-9.10, p = 0.02). In nonHispanic white men the T-C-G-A-A-T-C-C haplotype was associated with a high Gleason score (OR 1.44, 95% CI 1.06-1.96, p = 0.021). Conclusions: These data indicate that polymorphisms in SEMA3B and SEMA3F are associated with prostate cancer risk and poor prognosis in Hispanic and nonHispanic white men.

KW - continental population groups

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KW - prostatic neoplasms

KW - semaphorins

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