Self-reported sensitivity to chemical exposures in five clinical populations and healthy controls

Stefan S. Nawab, Claudia S. Miller, Janet K. Dale, Benjamin D. Greenberg, Theodore C. Friedman, George P. Chrousos, Stephen E. Straus, Norman E. Rosenthal

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Two hundred and twenty-five subjects, including normal volunteers and patients with previously documented seasonal affective disorder (SAD), chronic fatigue syndrome (CFS), Cushing's syndrome, Addison's disease and obsessive-compulsive disorder (OCD), completed a self-rated inventory of reported sensitivity to various chemical exposures. Patients with CFS, Addison's disease and SAD self-reported more sensitivity to chemical exposures than normal controls. In addition, women reported more sensitivity than men. This report suggests that chemical sensitivity may be a relevant area to explore in certain medical and psychiatric populations. A possible relationship between reported chemical sensitivity and hypothalamic-pituitary-adrenal (HPA)-axis functioning is discussed. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)67-74
Number of pages8
JournalPsychiatry Research
Issue number1
StatePublished - Jul 24 2000


  • Addison's disease
  • Chemical exposure
  • Chronic fatigue syndrome
  • Cushing's syndrome
  • Hypothalamic-pituitary-adrenal axis (HPA)
  • Multiple chemical sensitivity
  • Obsessive-compulsive disorder
  • Seasonal affective disorder

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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