Abstract
Differences in the glutaminergic modulation of afferent and intrinsic fiber synaptic transmission in piriform (olfactory) cortex were investigated using extracellular and intracellular recording techniques in a transverse slice preparation. 2-Amino-4-phosphonobutyric acid (AP4) strongly suppressed synaptic potentials evoked by afferent fiber stimulation in layer 1a, while having a much weaker effect on synaptic potentials evoked by intrinsic fiber stimulation in layer 1b. Both the racemic mixture and l-(+)-enantiometer of AP4 showed this differential effect. Suppression of afferent fiber synaptic potentials was accompanied by an increase in paired pulse facilitation, suggesting a pre-synaptic mechanism, while intrinsic fiber synaptic potentials showed little change in facilitation. Previous work has shown that cholinergic modulation in piriform cortex appears selective for intrinsic fiber synapses. The present data describes a pre-synaptic glutaminergic modulation complementary to the cholinergic modulation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 248-255 |
| Number of pages | 8 |
| Journal | Brain Research |
| Volume | 548 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - May 10 1991 |
| Externally published | Yes |
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Keywords
- Glutamine
- Lamination
- Olfactory
- Paired-pulse facilitation
- Presynaptic
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Selective suppression of afferent but not intrinsic fiber synaptic transmission by 2-amino-4-phosphonobutyric acid (AP4) in piriform cortex. / Hasselmo, Michael E.; Bower, James M.
In: Brain Research, Vol. 548, No. 1-2, 10.05.1991, p. 248-255.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selective suppression of afferent but not intrinsic fiber synaptic transmission by 2-amino-4-phosphonobutyric acid (AP4) in piriform cortex
AU - Hasselmo, Michael E.
AU - Bower, James M.
PY - 1991/5/10
Y1 - 1991/5/10
N2 - Differences in the glutaminergic modulation of afferent and intrinsic fiber synaptic transmission in piriform (olfactory) cortex were investigated using extracellular and intracellular recording techniques in a transverse slice preparation. 2-Amino-4-phosphonobutyric acid (AP4) strongly suppressed synaptic potentials evoked by afferent fiber stimulation in layer 1a, while having a much weaker effect on synaptic potentials evoked by intrinsic fiber stimulation in layer 1b. Both the racemic mixture and l-(+)-enantiometer of AP4 showed this differential effect. Suppression of afferent fiber synaptic potentials was accompanied by an increase in paired pulse facilitation, suggesting a pre-synaptic mechanism, while intrinsic fiber synaptic potentials showed little change in facilitation. Previous work has shown that cholinergic modulation in piriform cortex appears selective for intrinsic fiber synapses. The present data describes a pre-synaptic glutaminergic modulation complementary to the cholinergic modulation.
AB - Differences in the glutaminergic modulation of afferent and intrinsic fiber synaptic transmission in piriform (olfactory) cortex were investigated using extracellular and intracellular recording techniques in a transverse slice preparation. 2-Amino-4-phosphonobutyric acid (AP4) strongly suppressed synaptic potentials evoked by afferent fiber stimulation in layer 1a, while having a much weaker effect on synaptic potentials evoked by intrinsic fiber stimulation in layer 1b. Both the racemic mixture and l-(+)-enantiometer of AP4 showed this differential effect. Suppression of afferent fiber synaptic potentials was accompanied by an increase in paired pulse facilitation, suggesting a pre-synaptic mechanism, while intrinsic fiber synaptic potentials showed little change in facilitation. Previous work has shown that cholinergic modulation in piriform cortex appears selective for intrinsic fiber synapses. The present data describes a pre-synaptic glutaminergic modulation complementary to the cholinergic modulation.
KW - Glutamine
KW - Lamination
KW - Olfactory
KW - Paired-pulse facilitation
KW - Presynaptic
UR - http://www.scopus.com/inward/record.url?scp=0025884287&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025884287&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(91)91128-N
DO - 10.1016/0006-8993(91)91128-N
M3 - Article
C2 - 1651141
AN - SCOPUS:0025884287
VL - 548
SP - 248
EP - 255
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -