The in vitro response of peripheral blood lymphocytes from rabbits infected with Treponema pallidum was examined using various mitogens and avirulent Treponema reiteri. For the first 4 wk after treponemal infection, the response of lymphocytes from syphilitic rabbits to phytohemagglutinin and pokeweed mitogen was markedly reduced in comparison to uninfected controls. Lymphocytes from both groups of rabbits responded normally to class specific immunoglobulin anti sera (anti immunoglobulin M and anti immunoglobulin G) and T. reiteri.
ASJC Scopus subject areas
- Infectious Diseases