Selective programming of CCR10+ innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation

Jie Yang, Shaomin Hu, Luming Zhao, Daniel H. Kaplan, Gary H. Perdew, Na Xiong

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Innate lymphoid cells (ILCs) 'preferentially' localize into barrier tissues, where they function in tissue protection but can also contribute to inflammatory diseases. The mechanisms that regulate the establishment of ILCs in barrier tissues are poorly understood. Here we found that under steady-state conditions, ILCs in skin-draining lymph nodes (sLNs) were continuously activated to acquire regulatory properties and high expression of the chemokine receptor CCR10 for localization into the skin. CCR10 + ILCs promoted the homeostasis of skin-resident T cells and, reciprocally, their establishment in the skin required T cell-regulated homeostatic environments. CD207 + dendritic cells expressing the transcription factor Foxn1 were required for the proper generation of CCR10 + ILCs. These observations reveal mechanisms that underlie the specific programming and priming of skin-homing CCR10 + ILCs in the sLNs.

Original languageEnglish (US)
Pages (from-to)48-56
Number of pages9
JournalNature Immunology
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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