Selective killing of normal or neoplastic B cells by antibodies coupled to the A chain of ricin

K. A. Krolick, C. Villemez, P. Isakson, J. W. Uhr, E. S. Vitetta

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Highly specific antibodies (affinity-purified or hybridoma) directed against cell surface immunoglobulins on normal or neoplastic murine B lymphocytes were covalently coupled to the A chain of the plant toxin ricin. Such conjugates containing antibodies specific for IgM, for either of the two allotypes of IgD, or for the idiotype of the B cell tumor BCL 1 rapidly bound in vitro to cells expressing the corresponding surface antigen and inhibited protein synthesis in such cells. The results demonstrate that A chain-coupled anti-idiotype antibody may be useful as a tumor-specific cytotoxic agent.

Original languageEnglish (US)
Pages (from-to)5419-5423
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number9 II
Publication statusPublished - Dec 1 1980


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