Selective intraarterial gene delivery into a canine meningioma

Anne E. Chauvet, Prabhakar P. Kesava, Chern Sing Goh, Behnam Badie

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Object. The goal of this study was to evaluate gene delivery to a benign brain tumor. Methods. A recombinant adenovirus vector bearing the Escherichia coli β-galactosidase reporter gene was selectively injected into the vascular supply of a spontaneously occurring canine olfactory groove meningioma. The tumor and a small amount of peritumoral brain tissue were removed 5 days after viral injection and stained with X-Gal to assess gene delivery. The authors noted significant β-galactosidase gene expression by the tumor, but not by surrounding brain tissue. No obvious viral-related cytotoxicity was noted. Conclusions. The authors found that meningiomas can be successfully transduced by adenovirus vectors by using endovascular techniques.

Original languageEnglish (US)
Pages (from-to)870-873
Number of pages4
JournalJournal of neurosurgery
Volume88
Issue number5
DOIs
StatePublished - May 1998
Externally publishedYes

Keywords

  • Adenoviral vector
  • Dog
  • Gene therapy
  • Intracarotid injection
  • Meningioma

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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