Selective inhibitors of human mPGES-1 from structure-based computational screening

Ziyuan Zhou, Yaxia Yuan, Shuo Zhou, Kai Ding, Fang Zheng, Chang Guo Zhan

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Human mPGES-1 is recognized as a promising target for next generation of anti-inflammatory drugs. Although various mPGES-1 inhibitors have been reported in literature, few have entered clinical trials and none has been proven clinically useful so far. It is highly desired for developing the next generation of therapeutics for inflammation-related diseases to design and discover novel inhibitors of mPGES-1 with new scaffolds. Here, we report the identification of a series of new, potent and selective inhibitors of human mPGES-1 with diverse scaffolds through combined computational and experimental studies. The computationally modeled binding structures of these new inhibitors of mPGES-1 provide some interesting clues for rational design of modified structures of the inhibitors to more favorably bind with mPGES-1.

Original languageEnglish (US)
Pages (from-to)3739-3743
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume27
Issue number16
DOIs
StatePublished - 2017
Externally publishedYes

Keywords

  • Inflammation
  • Inhibitor identification
  • Prostaglandin
  • Selective inhibitor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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