Abstract
Combinations of aminoglycoside and beta-lactam antibiotics may act synergistically against certain microorganisms. However, aminoglycosides have been shown to interact chemically with certain beta-lactam antibiotics resulting in diminished activity of the aminoglycoside. Two beta-lactam antiotics, moxalactam and cefotaxime, as well as several other beta-lactams in current use, were studied for possible inactivation of gentamicin, tobramycin and amikacin. Aqueous mixtures of each of the three aminoglycosides plus a beta-lactam antibiotic (moxalactam, cefotaxime, cephalothin, carbenicillin, ticarcillin or penicillin) were prepared in ratios of 10:1 and 50:1 (beta-lactam: aminoglycoside). Gentamicin and tobramycin were markedly inactivated by carbenicillin and ticarcillin, and to a lesser degree by penicillin (only at the 50:1 ratio), but not by cephalothin, cefotaxime, or moxalactam. Conversely, amikacin was significantly inactivated by cephalothin and moxalactam, by ticarcillin only at a 50:1 ratio, and was not significantly inactivated by carbenicillin, penicillin, or cefotaxime. Thus, there were selective differences in the susceptibilities of the aminoglycosides to inactivation as well as differences in the propensities of certain beta-lactam antibiotics to cause inactivation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 25-35 |
| Number of pages | 11 |
| Journal | Current Therapeutic Research - Clinical and Experimental |
| Volume | 32 |
| Issue number | 1 I |
| State | Published - 1982 |
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Cite this
Selective inactivation of aminoglycosides by newer beta-lactam antibiotics. / Jorgensen, J. H.; Crawford, S. A.
In: Current Therapeutic Research - Clinical and Experimental, Vol. 32, No. 1 I, 1982, p. 25-35.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selective inactivation of aminoglycosides by newer beta-lactam antibiotics
AU - Jorgensen, J. H.
AU - Crawford, S. A.
PY - 1982
Y1 - 1982
N2 - Combinations of aminoglycoside and beta-lactam antibiotics may act synergistically against certain microorganisms. However, aminoglycosides have been shown to interact chemically with certain beta-lactam antibiotics resulting in diminished activity of the aminoglycoside. Two beta-lactam antiotics, moxalactam and cefotaxime, as well as several other beta-lactams in current use, were studied for possible inactivation of gentamicin, tobramycin and amikacin. Aqueous mixtures of each of the three aminoglycosides plus a beta-lactam antibiotic (moxalactam, cefotaxime, cephalothin, carbenicillin, ticarcillin or penicillin) were prepared in ratios of 10:1 and 50:1 (beta-lactam: aminoglycoside). Gentamicin and tobramycin were markedly inactivated by carbenicillin and ticarcillin, and to a lesser degree by penicillin (only at the 50:1 ratio), but not by cephalothin, cefotaxime, or moxalactam. Conversely, amikacin was significantly inactivated by cephalothin and moxalactam, by ticarcillin only at a 50:1 ratio, and was not significantly inactivated by carbenicillin, penicillin, or cefotaxime. Thus, there were selective differences in the susceptibilities of the aminoglycosides to inactivation as well as differences in the propensities of certain beta-lactam antibiotics to cause inactivation.
AB - Combinations of aminoglycoside and beta-lactam antibiotics may act synergistically against certain microorganisms. However, aminoglycosides have been shown to interact chemically with certain beta-lactam antibiotics resulting in diminished activity of the aminoglycoside. Two beta-lactam antiotics, moxalactam and cefotaxime, as well as several other beta-lactams in current use, were studied for possible inactivation of gentamicin, tobramycin and amikacin. Aqueous mixtures of each of the three aminoglycosides plus a beta-lactam antibiotic (moxalactam, cefotaxime, cephalothin, carbenicillin, ticarcillin or penicillin) were prepared in ratios of 10:1 and 50:1 (beta-lactam: aminoglycoside). Gentamicin and tobramycin were markedly inactivated by carbenicillin and ticarcillin, and to a lesser degree by penicillin (only at the 50:1 ratio), but not by cephalothin, cefotaxime, or moxalactam. Conversely, amikacin was significantly inactivated by cephalothin and moxalactam, by ticarcillin only at a 50:1 ratio, and was not significantly inactivated by carbenicillin, penicillin, or cefotaxime. Thus, there were selective differences in the susceptibilities of the aminoglycosides to inactivation as well as differences in the propensities of certain beta-lactam antibiotics to cause inactivation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020393171&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0020393171
VL - 32
SP - 25
EP - 35
JO - Current Therapeutic Research
JF - Current Therapeutic Research
SN - 0011-393X
IS - 1 I
ER -