Abstract
A variety of diseases are the result of identifiable cell types entering an abnormal state of development in which they escape existing mechanisms that regulate their growth or other functional activities. A variety of investigators interested in eliminating cells that have undergone malignant transformation have devised immunotherapeutic approaches based on the construction of hybrid molecules composed of highly toxic biological poisons covalently coupled with antibodies specific for membrane antigens expressed selectively by tumor cell targets. This strategy can be further exploited to eliminate any target cell with defined, selectively expressed membrane antigens. The following discussion describes possible uses of such an approach for achieving selective cytotoxicity of lymphocytes with undesirable immunoreactivities, such as those found in autoimmune disease and graft-versus-host disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 273-282 |
| Number of pages | 10 |
| Journal | Clinical Immunology and Immunopathology |
| Volume | 50 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1989 |
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ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
- Pathology and Forensic Medicine
Cite this
Selective elimination of autoreactive lymphocytes with immunotoxins. / Krolick, Keith A.
In: Clinical Immunology and Immunopathology, Vol. 50, No. 3, 1989, p. 273-282.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selective elimination of autoreactive lymphocytes with immunotoxins
AU - Krolick, Keith A
PY - 1989
Y1 - 1989
N2 - A variety of diseases are the result of identifiable cell types entering an abnormal state of development in which they escape existing mechanisms that regulate their growth or other functional activities. A variety of investigators interested in eliminating cells that have undergone malignant transformation have devised immunotherapeutic approaches based on the construction of hybrid molecules composed of highly toxic biological poisons covalently coupled with antibodies specific for membrane antigens expressed selectively by tumor cell targets. This strategy can be further exploited to eliminate any target cell with defined, selectively expressed membrane antigens. The following discussion describes possible uses of such an approach for achieving selective cytotoxicity of lymphocytes with undesirable immunoreactivities, such as those found in autoimmune disease and graft-versus-host disease.
AB - A variety of diseases are the result of identifiable cell types entering an abnormal state of development in which they escape existing mechanisms that regulate their growth or other functional activities. A variety of investigators interested in eliminating cells that have undergone malignant transformation have devised immunotherapeutic approaches based on the construction of hybrid molecules composed of highly toxic biological poisons covalently coupled with antibodies specific for membrane antigens expressed selectively by tumor cell targets. This strategy can be further exploited to eliminate any target cell with defined, selectively expressed membrane antigens. The following discussion describes possible uses of such an approach for achieving selective cytotoxicity of lymphocytes with undesirable immunoreactivities, such as those found in autoimmune disease and graft-versus-host disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024573726&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(89)90136-0
DO - 10.1016/0090-1229(89)90136-0
M3 - Article
VL - 50
SP - 273
EP - 282
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
IS - 3
ER -