Abstract
We have investigated the role of the sympathetic innervation of the vasculature of the head in the control of selective brain cooling of sheep, during exposure to high and low ambient temperatures and during endotoxin-induced fever. Bilateral removal of the superior cervical ganglia resulted in a significant reduciton of hypothalamic temperture during all procedures. Respiratory rate was also depressed by the sympathectomy, apparently mainly as a result of a decrease in nasal airway patency. Rectal temperature changes after sympathectomy were dependent on the experimental conditions, and the rectal - hypothalamic temperature difference was enhanced during heat exposure and fever. Our results support the contention that sympathetically mediated changes in nasal blood flow and in venous return from the nasal cavity, via the angularis oculi and facial veins, may be involved in the control of selective brain cooling in sheep.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 375-381 |
| Number of pages | 7 |
| Journal | Pflügers Archiv European Journal of Physiology |
| Volume | 417 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 1 1990 |
| Externally published | Yes |
Keywords
- Body temperature
- Brain temperature
- Sympathetic nervous system
- Thermoregulation
- fever
- α-adrenergic
- β-adrenergic
ASJC Scopus subject areas
- Physiology
- Clinical Biochemistry
- Physiology (medical)