Selective brain cooling after bilateral superior cervical sympathectomy in sheep (Ovis aries)

Mark J Nijland, Duncan Mitchell, Graham Mitchell

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We have investigated the role of the sympathetic innervation of the vasculature of the head in the control of selective brain cooling of sheep, during exposure to high and low ambient temperatures and during endotoxin-induced fever. Bilateral removal of the superior cervical ganglia resulted in a significant reduciton of hypothalamic temperture during all procedures. Respiratory rate was also depressed by the sympathectomy, apparently mainly as a result of a decrease in nasal airway patency. Rectal temperature changes after sympathectomy were dependent on the experimental conditions, and the rectal - hypothalamic temperature difference was enhanced during heat exposure and fever. Our results support the contention that sympathetically mediated changes in nasal blood flow and in venous return from the nasal cavity, via the angularis oculi and facial veins, may be involved in the control of selective brain cooling in sheep.

Original languageEnglish (US)
Pages (from-to)375-381
Number of pages7
JournalPflügers Archiv European Journal of Physiology
Volume417
Issue number4
DOIs
StatePublished - Dec 1990
Externally publishedYes

Fingerprint

Domestic Sheep
Sympathectomy
Brain
Sheep
Cooling
Nose
Temperature
Fever
Superior Cervical Ganglion
Nasal Cavity
Respiratory Rate
Endotoxins
Veins
Blood
Hot Temperature
Head

Keywords

  • α-adrenergic
  • β-adrenergic
  • Body temperature
  • Brain temperature
  • fever
  • Sympathetic nervous system
  • Thermoregulation

ASJC Scopus subject areas

  • Physiology

Cite this

Selective brain cooling after bilateral superior cervical sympathectomy in sheep (Ovis aries). / Nijland, Mark J; Mitchell, Duncan; Mitchell, Graham.

In: Pflügers Archiv European Journal of Physiology, Vol. 417, No. 4, 12.1990, p. 375-381.

Research output: Contribution to journalArticle

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